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Clinical Trial Details

Overview

Research Study Summary

A clinical research study of 100 mg enteric-coated aspirin and Placebo

Research Study Title

Aspirin in Reducing Events in the Elderly

Purpose

The ASPREE study will examine whether the potential benefits of low dose aspirin (particularly preventing heart disease, stroke, certain cancers and dementia) outweigh the risks (particularly bleeding) in people over age 65.

ASPREE will determine whether taking a daily low-dose aspirin will extend the length of a disability-free life in healthy participants aged 65 years and above.

To Learn more
Phase

4

Gender

Both Male and Female

Age

65 and up

Overall Status

Recruiting

Lead Sponsor

Minneapolis Medical Research Foundation

Duration

84 Months

Facility Type

N/A

Eligibility

Both Male and Female ages 65 Years and up

Inclusion Criteria:

  • Men and women

  • African American and Hispanic persons age 65 or older

  • Any person from another ethnic minority group age 70 or older

  • Willing and able to provide informed consent, and willing to accept the study requirements

[ASPREE has completed enrollment of Caucasian participants in the US.]

Exclusion Criteria:

  • A history of a diagnosed cardiovascular event

  • A serious intercurrent illness likely to cause death within the next 5 years, such as terminal cancer or obstructive airways disease

  • A current or recurrent condition with a high risk of major bleeding, ex: cerebral aneurysm

  • Anemia

  • Absolute contraindication or allergy to aspirin

  • Current participation in a clinical trial

  • Current continuous use of aspirin or other anti-platelet drug or anticoagulant for secondary prevention. People with previous use of aspirin for primary prevention may enter the trial, provided they agree to cease existing use of aspirin and understand that they may be subsequently randomly allocated to low dose aspirin or placebo.

  • A systolic blood pressure ≥180 mmHg and / or a diastolic blood pressure ≥105 mmHg

  • A history of dementia

  • Severe difficulty or an inability to perform any one of the 6 Katz ADLs

  • Non-compliance to taking pill

Site Locations (39)

Country State City Zip Facility and Contact
United States Alabama Birmingham 35294 The University of Alabama at Birmingham
Cathy Stallings
205-934-7683

Beth Lewis, MD
Principal Investigator
United States California Palo Alto 94301 Palo Alto Medical Foundation Research Institute
Elsie Wang
650-853-2871

Latha Palaniappan, MD
Principal Investigator
United States District of Columbia Washington 20060 Howard University
Oludolapo Ogunlana
202-865-1973

Thomas Obisesan, MD
Principal Investigator
United States Florida Gainsville 32611 University of Florida Department of Aging and Geriatrics
Emily Chappelle
352-273-5919

Steven Anton, MD
Principal Investigator
United States Georgia Atlanta 30322 Emory/ Atlanta VAMC
Stephanie Stennett
404-321-6111 ext. 7364

Peter Wilson, MD
Principal Investigator
United States Georgia Atlanta 30310 Morehouse School of Medicine
Connie Jones
404-752-1133

Pricilla Pema, MD
Principal Investigator
United States Georgia Augusta 30912 Georgia Health Sciences University
Darlene Gibson
706-721-4335
dagibson@gru.edu

Daron Ferris, MD
Principal Investigator
United States Illinois Chicago 60612 Rush Alzheimer's Disease Center
Karen Graham
312-942-6118

Raj Shah, MD
Principal Investigator
United States Iowa Iowa City 52242 University of Iowa
Michael Ernst
319-384-7756

Michael Ernst, PharmD
Principal Investigator
United States Kansas Kansas City 66106 Kansas University Medical Center
Natalya Stolyar
913-945-7676

Jeffery Burns, MD
Principal Investigator
United States Louisiana Baton Rouge 70808 Pennington Biomedical Research Center
Heidi Millet
225-763-3089

Timothy Church, MD
Principal Investigator
United States Louisiana Baton Rouge 70809 Mary Bird Perkins Our Lady of the Lake Cancer Center
Dawn Rachal
225-215-1185
drachal@marybird.com

David Hanson, MD
Principal Investigator
United States Louisiana Baton Rouge 70801 Baton Rouge General
Heidi Millet
225-763-3089
Heidi.Millet@pbrc.edu

Timothy Church, MD
Principal Investigator
United States Louisiana Covington 70433 Mary Bird Perkins St. Tammany Parish Hospital
Julie Nunez
jnunez@marybird.com

Patricia Braly, MD
Principal Investigator
United States Louisiana Houma 70360 Mary Bird Perkins Terrebonne General Hospital
Ann Toups
Ann.toups@tgmc.com

Raul Doria, MD
Principal Investigator
United States Louisiana New Orleans 70112 LSU Health Sciences- New Orleans
Renee Jenkins
504-568-2108
rjenk4@lsuhsc.edu

Augusto Ochoa, MD
Principal Investigator
United States Louisiana New Orleans 70112 Tulane Medical Center
Alexandria Augustus
504-988-6124
aaugustu@tulane.edu

William Robinson III, MD
Principal Investigator
United States Louisiana Shreveport 71130 LSU Health Sciences- Shreveport
Lori Panu
318-813-1405
lpanu@lsuhsc.edu

Gary Burton, MD
Principal Investigator
United States Michigan Ann Arbor 48109 University of Michigan
Denise Cornish
734-998-7947

Jocelyn Wiggins, MD
Principal Investigator
United States Michigan Detroit 48201 Wayne State University
Elisabeta Levcovici
313-993-0419

John Flack, MD
Principal Investigator
United States Michigan Novi 48377 Detroit Clinical Research Center
Sonia Amin
248-773-8979

Mutahhar Ahmad, MD
Principal Investigator
United States Minnesota Minneapolis 55425 Health Partners Research Foundation
Rachel Pritchard
612-341-1957

Karen Margolis, MD
Principal Investigator
United States Minnesota St. Paul 55106 Phalen Village Clinic
Lea Seaquist
651-793-8640

Kevin Peterson, MD
Principal Investigator
United States New Jersey Elizabeth 07202 Central Jersey Medical Center
Namrata Thakkar
908-576-8038

Mandeep Oberoi, MD
Principal Investigator
United States New Jersey Newark 07103 New Jersey Medical College
Yasmeen Beckett
973-972-3173
barberys@umdnj.edu

Robert Wieder, MD, PhD
Principal Investigator
United States New York Brooklyn 11203 SUNY Downstate Medical Center
Nikita Watson
718-270-2931
nikita.watson@downstate.edu

Karen Benker, MD
Principal Investigator
United States New York Mineola 11501 Winthrop University Hospital
Migdalia Reid
516-663-2592

John Aloia, MD
Principal Investigator
United States New York Queens 11432 Queens Cancer Medical Center
Linda Bulone, RN
718-883-3751
bulonel@nychhc.org

Parampreet Bakshi, MD
Principal Investigator
United States North Carolina Greensboro 27408 Wake Forest University Baptist Medical Center
Patricia Wittmer
336-713-8243

Jamehl Demons, MD
Principal Investigator
United States North Carolina Greenville 27834 The Brody School of Medicine at ECU
Brittany Brown
252-744-1904

James Powell, MD
Principal Investigator
United States Pennsylvania Philadelphia 19141 Albert Einstein Medical Center
Julie Whinner
215-456-1959

Gregg Pressman, MD
Principal Investigator
United States Pennsylvania Pittsburgh 15260 University of Pittsburgh Health Sciences Research Center
Cheryl Albig
412-383-1470

Anne Newman, MD, MPH
Principal Investigator
United States Rhode Island Pawtucket 02860 Memorial Hospital of Rhode Island
Liz Coccio
401-729-2183

Charles Eaton, MD
Principal Investigator
United States Tennessee Memphis 38105 University of Tennessee Health Science Center
Margaret Caulfield
901-448-6732

Suzanne Satterfield, MD
Principal Investigator
United States Tennessee Nashville 57208 Meharry Medical College
Donna Skupien
615-327-5725
dskupien@mmc.edu

John Murray, MD
Principal Investigator
United States Texas Dallas 75390 University of Texas Southwestern Medical Center at Dallas
Pat Knowles
214-648-3612

Shawna Nesbitt, MD, MS
Principal Investigator
United States Texas Galveston 77555 University of TX Medical Branch
Roxana Hirst
409-266-9641

Elena Volpi, MD
Principal Investigator
United States Texas Harlingen 78550 Regional Academic Health Center
Julia Zuniga
956-365-8688
zunigaj3@uthscsa.edu

Sarah Espinoza, MD
Principal Investigator
United States Texas San Antonio 78229 UT Health Science Center at San Antonio
Melissa Navarro
210-450-0550

Sarah Espinoza, MD
Principal Investigator

Contact

Nathan J Tessum
612-341-7907
E-mail:

NCT ID: NCT01038583

Date Last Changed: May 16, 2014

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