Research Study Summary
A clinical trial to evaluate treatments using Pregabalin and Placebo for patients with Anxiety
Research Study Title
The Short and Long Term Effects of Perioperative Pregabalin Use on Functional Rehabilitation, Pain Outcomes and Anxiety Following Total Hip Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
Pain prior to surgery is of particular concern in patients undergoing total hip arthroplasty
(THA) since it is the most important predictor of pain and poor function 2-3 years after
surgery. Previous studies have investigated various treatments for managing pain during and
after surgery. However, no study has investigated the short and long term effects of
pregabalin in terms of functional rehabilitation, pain outcome and anxiety following total
hip arthroplasty. Therefore, the aim of the present study is determine if the following:
(1) if perioperative pregabalin administration positively influence early rehabilitation and
recovery of physical function and to determine if these effects maintained at 6 weeks and 3
months post surgery. (2) To determine if perioperative pregabalin administration reduce
postoperative movement evoked pain associated with rehabilitation and if these effects also
maintained at 6 weeks and 3 months post surgery.
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