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Clinical Trial Details


Research Study Summary

A Phase 2 clinical study for patients with Alzheimer's Disease

Research Study Title

Phase 2 (Feasibility) Study of Transcranial Magnetic Stimulation as Additional Therapy to Drug Treatment in Patients With Alzheimer's Disease


The primary objective of this trial is to assess the ability of Transcranial Magnetic Stimulation with H2 coil to prefrontal and parieto-temporal cortex to improve cognitive performance in patients with Alzheimer's disease which received drug treatment. This study is a single-center, double-blind 4 months duration trial.

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Both Male and Female


50 to 80 Years

Overall Status


Lead Sponsor

Tel-Aviv Sourasky Medical Center


48 Months

Facility Type



Both Male and Female ages 50 Years to 80 Years

Inclusion Criteria:

  • Written informed consent will be obtained

  • diagnostic evidence of probable AD consistent with DSM IV

  • stable treatment with Acetylcholine-Esterase Inhibitors or/and Memantine for 5 weeks prior to screening

  • stable dose treatment with other drugs

  • MMSE < 25

Exclusion Criteria:

  • Patients with neurological or psychiatric disorders that affect cognition but are distinguishable from AD

  • Patients who are unwilling or unable to fulfill the requirements of the study

  • Severe personality disorder

  • Malignant or untreated Hypertension

  • History of Epilepsy

  • History of Head trauma

  • Metal implant in head, cardiac pacemaker, medical pump

  • Drug or alcohol addiction

  • Involvement in any other clinical trial during the preceding 3 month

  • Patient who are unwilling or unable to give Informed Consent

Site Locations (1)

Country State City Zip Facility and Contact
Israel Tel Aviv 64239 Tel Aviv Sourasky Medical Center, Neurology Department
Alissa Ash, Dr.


Alissa Ash, Dr.

NCT ID: NCT00753662

Date Last Changed: September 12, 2011

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