Research Study Summary
A clinical research study of Pemetrexed + Cisplatin or Carboplatin AUC=5 Pleurectomy/decortication (if feasible) Intensity Modulated Radiation Therapy for the treatment of Mesothelioma
Research Study Title
Phase II Toxicity Study of Pleurectomy/Decortication Followed By Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma
For patients with this type of cancer, the standard of care is treatment with chemotherapy.
Radiation therapy is typically not used. This is because radiation to the entire lining of
the lung has many side effects that are often severe including damage to the lung
(pneumonitis). There is a new radiation technique using Intensity Modulated Radiation
Therapy (IMRT) that has been shown to reduce many of the side effects of standard radiation
therapy. This type of radiation therapy specifically targets the lining of the lung, where
you have your cancer, and reduces the risk of damaging the lung itself. The purpose of this
study is to test the safety and implementation of standard pleurectomy/decortication
(removal of the surface lining of the lung) performed at other centers. Patients will
undergo pleurectomy/decortication followed by chemotherapy then hemithoracic pleural IMRT to
the pleura in patients with malignant pleural mesothelioma.
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