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Clinical Trial Details
Research Study Summary
A clinical trial to evaluate treatments using Memantine for patients with Alzheimer's Disease
Research Study Title
The Effect of Memantine on Aggression and Agitation and Its Impact on Caregiver Burden of Patients With Alzheimer's Disease: A 12-week Open-label Study
Alzheimer's disease (AD), is associated with behavioral disturbances in approximately 50% of
AD patients in Beijing. Agitation, and aggression specifically, is considered the most
serious noncognitive symptom experienced in patients with dementia. Memantine is a
recognized treatment for Alzheimer's disease either alone or in combination with
cholinesterase inhibitors. Its efficacy in vascular dementia is also established. Family
members continue to play a central role in home care for the demented elderly in China. This
proposal is to conduct a study in Beijing, China to investigate the efficacy and safety of
Memantine in the treatment of agitation and aggression in AD patients. In addition, this
proposal aims to explore the impact of memantine on caregiver burden of AD patients in
To Learn more
Both Male and Female
Both Male and Female ages 50 Years and up
Written informed consent
Clinical diagnosis of Alzheimer's disease.
Having at least a minimum aggression score on the Cohen-Mansfield Agitation Inventory
(CMAI): a score of ≥ 4 on at least 1 aggressive item, or a score of 3 on at least 2
aggressive items, or a score of 2 on at least 3 aggressive items, or 2 aggressive
items occurring at a frequency of 2 and 1 at a frequency of 3.
Availability of a responsible family member or carer to ensure treatment compliance
and provide information for informant assessments.
Unavailability of a responsible family member or carer
Severe renal impairment.
History of seizures
Diagnosis of any concomitant life threatening illness.
Site Locations (1)
||Peking University Institute of Mental Health
Huali Wang, MD, PhD
Huali Wang, MD, PhD
Tao Li, MD
NCT ID: NCT00703430
Date Last Changed: January 24, 2013
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