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Home » Clinical Trials » Alzheimer's Disease

Clinical Trial Details

Overview

Research Study Summary

A clinical research study of Experimental 1 and Placebo Comparator for the treatment of Alzheimer's Disease

Research Study Title

Assessment of the Comparative Effect of Donepezil 10mg/d and Placebo on Clinical and Radiological Markers in Patients With Mild Cognitive Disorders

Purpose

The purpose of this study is to demonstrate that donepezil slows the progression of Alzheimer's disease (AD) using magnetic resonance imaging (MRI) of the brain to measure the volume of the hippocampus in patients with pre-dementia Alzheimer's disease.

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Phase

4

Gender

Both Male and Female

Age

50 and up

Overall Status

Recruiting

Lead Sponsor

Eisai Inc.

Duration

16 Months

Facility Type

N/A

Eligibility

Both Male and Female ages 50 Years and up

Inclusion Criteria (Baseline Visit ("V0"):

1.Men or Women 50 years old or more. 2. Patients with mild cognitive impairment (MCI) with progressive hippocampal amnestic syndrome, isolated or associated to other cognitive disorders defined by the Free and cued selective reminding test ( FCSRT ) with Free Recall < or = 17 OR Total Recall < 40 , according to the Grober and Buschke procedure, modified according to the results of PREAL study 3.Clinical Dementia Rating (CDR) = 0.5 4. General cognition and functional performance sufficiently preserved such that a diagnosis of Possible or Probable Alzheimer's Disease based on Diagnostic and Statistical Manual of Mental Disorders DSM-IV criteria) cannot be made by the site physician at the time of the screening visit. This evidence must be fully documented in the subject's study file before the Randomization visit.

  1. Outpatient with an informant person: person from his/her close circle having a regular weekly contact with the patient and accepting to answer to assessment questionnaires.

  2. Visual, hearing capacities (authorized equipment) and oral or written expression, sufficient for the correct performance of the tests (according to the physician's opinion).

  3. Patient and informant person having signed the written informed consent form.

Exclusion Criteria (Baseline Visit ("V0"):

  1. Patients with a contraindication to MRI:

  2. Pacemaker, cardiac defibrillator or neurostimulator wearers

  3. Wearers of implanted material activated by an electric, magnetic or mechanical system

  4. Wearers of haemostatic clips of intracerebral aneurysms or carotid arteries

  5. Wearers of cochlear implants

  6. Patients with an intraocular metallic foreign body

  7. Claustrophobic patients

  8. Any other contra-indication to MRI

  9. Patients with an evolutive psychiatric pathology and/or unstable according to DSM-IV, particularly:

  10. Major depressive episode during the previous 2 years or recurrent depression or bipolar disorders according to the DSM-IV and/or score > = 12 according to the 17-items depressive Hamilton's Scale

  11. Patients presenting early hallucinations or cognitive fluctuations

  12. Patients with neurological disorders:

  13. Partial complex epilepsy

  14. Dementia of any origin

  15. Patients with Parkinson's disease

  16. Any patient with a history of an intercurrent lesion found in brain imaging studies.

  17. Patient presenting a major repercussion on the autonomy, assessed by Instrumental Activities of Daily Living (IADL) Lawton score higher or equal to 2 in at least 2 items or higher than 2 in at least 1 item, confirmed by an informant person.

  18. Patient having less than 14 words at the identification phase of the FCSRT (Free and Cued Selective Reminding Test)

  19. Known vitamin B12 or folates deficiency (except if replacement treatment of stable posology since at least 6 months before selection) or known syphilis.

  20. Abnormal Thyroid function (T3, T4, ultrasensitive thyroid stimulating hormone (TSH). Euthyroid patients treated with stable doses for at least 3 months could be included.

  21. Insulin dependent diabetes or diabetes not controlled by a regimen and/or oral antidiabetics, obstructive pulmonary disease, unstable asthma, recent hematological and/or oncological disorders (2 years).

  22. Gastrointestinal, renal, hepatic, endocrine or cardiovascular clinically significant disease. Atrioventricular block of 2nd or 3rd degree on ECG.

  23. Patient with bradycardia < or = 50 beats per minute.

  24. Patient with unstable hypertension (systolic blood pressure > 160 mmHg and /or diastolic blood pressure > 95 mmHg) assessed by the investigator, the patient being treated or not by antihypertensive drugs.

  25. Patient previously treated with central cholinesterase inhibitors or memantine whatever the duration of the treatment and the date of prescription

  26. Patient treated by a non-authorized drug during the study

  27. Known or suspected history (5 years) of alcoholism, or abusive drug use.

  28. Patients with known hypersensitivity to donepezil chlorhydrate, to piperidine derivatives or to one of the excipients of the drug.

  29. Patients having participated in a clinical trial during the previous 3 months.

Inclusion criteria (Visit 1):

  1. Patients with mild cognitive impairment (MCI) with progressive hippocampal amnestic syndrome, isolated or associated to other cognitive disorders

  2. General cognition and functional performance sufficiently preserved such that a diagnosis of Possible or Probable Alzheimer's Disease based on clinical and neuro-imaging findings (NINCDS-ADRDA or DSM-IV criteria) cannot be made by the site physician at the time of the screening visit. This evidence must be fully documented in the subject's study file.

  3. Outpatient with an informant person: person from his/her close circle having a regular weekly contact with the patient and accepting to answer to assessment questionnaires

  4. Patients having performed an electrocardiogram (ECG) within the previous 6 months

  5. Visual, hearing capacities (authorized equipment) and oral or written expression, sufficient for the correct performance of the tests (according to the physician's opinion)

  6. Clinical laboratory values must be within normal limits, or if abnormal, judged clinically insignificant by the investigator (not likely to cause cognitive impairment or medical instability)

  7. Clinical Dementia Rating (CDR - sum of the boxes) = 0.5

Exclusion criteria (Visit 1):

  1. Patients with an evolutive psychiatric pathology and/or unstable according to DSM-IV, particularly:

  2. Major depressive episode ongoing or recurrent depression or bipolar disorders according to the DSM-IV and/or score > or = 12 according to the 17-items depressive Hamilton's Scale

  3. Patients presenting early hallucinations or cognitive fluctuations

  4. Any patient presenting with an intercurrent lesion in MRI performed at screening must be excluded from the study, apart from minor non-progressive lesions not altering brain morphology

  5. Patients with neurological disorders :

  6. Partial complex epilepsy

  7. Dementia of any origin

  8. Patients with Parkinson's disease

  9. Patient with One or more MRI Exclusion criteria :

  10. Stroke sequelae

  11. More than one ischemic lacuna

  12. Age related white matter changes on Flair images > Fazekas and Schmidt grade 2

  13. Active ischemic lesion on Diffusion weighted Images (DWI)

  14. Patient presenting a major repercussion on the autonomy, assessed by IADL Lawton score higher or equal to 2 in at least 2 items or higher than 2 in at least 1 item, confirmed by an informant person.

  15. Known vitamin B12 or folates deficiency (except if replacement treatment of stable posology since at least 6 months before selection) or known syphilis.

  16. Abnormal Thyroid function (T3, T4, free thyroxine index, TSH). Euthyroid patients treated with stable doses for at least 3 months could be included.

  17. Insulin dependent diabetes or diabetes not controlled by a regimen and/or oral antidiabetics, obstructive pulmonary disease, unstable asthma, recent hematological and/or oncological disorders ( < = 2 years).

  18. Gastrointestinal, renal, hepatic, endocrine or cardiovascular clinically significant disease. Atrioventricular block of 2nd or 3rd degree on ECG.

  19. Patients with bradycardia < = 50.

  20. Patients with unstable hypertension (systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 95mmHg) assessed by the investigator, the patient being treated or not by anti hypertensive drugs.

  21. Patient previously treated with central cholinesterase inhibitors or memantine whatever the duration of the treatment and the date of prescription

  22. Patient treated by a non-authorized drug during the study

  23. Known or suspected history ( < = 5 years) of alcoholism, or abusive drug use.

  24. Patients with known hypersensitivity to donepezil chlorhydrate, to piperidine derivatives or to one of the excipients of the drug.

  25. Patients having participated in a clinical trial during the previous 3 months.

  26. Patient treated by a non-authorized drug during the study.

Site Locations (1)

Country State City Zip Facility and Contact
France Montpellier cedex CHU Gui de Chauliac

Contact

Eisai France
00 33 1 47 67 00 05

NCT ID: NCT00403520

Date Last Changed: October 7, 2010

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