Clinical Trial Details

NCT ID: NCT00203333
Date Last Changed: November 5, 2014


Research Study Summary

A clinical trial to evaluate treatments using Medtronic REVEAL for patients with Refractory Epilepsy, Arrhythmia or Sudden Death

Research Study Title

Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death


People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population, accounting for 10-50% of deaths for those with epilepsy. The risk for SUDEP is particularly high for those with refractory epilepsy. Several lines of evidence support a cardiac mechanism for SUDEP.

This study plans to determine:

  1. the frequency and types of cardiac arrhythmias that occur in this population and

  2. whether these are increased above the general population in the same age group.

Additionally, these data will be correlated to specific clinical data, including seizure history, anticonvulsant medications, and any accompanying clinical symptoms.

To Learn more

Recruitment Details

Both Male and Female
16 to 49 Years
Overall Status
Lead Sponsor
Thomas Jefferson University
Facility Type


Both Male and Female ages 16 Years to 49 Years

Inclusion Criteria:

  • Refractory epilepsy

Exclusion Criteria:

  • Other pre-existing heart conditions

Site Locations (1)

Country State City Zip Facility and Contact
United States Pennsylvania Philadelphia 19107 Thomas Jefferson University
Megan Morales, BA

Maromi Nei, MD
Principal Investigator


Gwen Taylor, BA

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