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Hepatic Porphyria Clinical Trials

A listing of Hepatic Porphyria medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (9) clinical trials

A research study is evaluating the prevalence of Acute Hepatic Porphyria (AHP) in adults with explained and untreatable abdominal pain.

Phase N/A

The objective of this clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy compared to an angiography-guided stent implantation strategy in achieving larger post-PCI lumen dimensions and improving clinical cardiovascular outcomes in patients with high-risk clinical characteristics and/or with high-risk angiographic lesions.

Phase N/A

EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

The purpose of this study is to characterize the natural history and clinical management of Acute Hepatic Porphyria (AHP) patients with recurring attacks.

Phase N/A

Harvoni Treatment Porphyria Cutanea Tarda

This is a clinical trial, which means its purpose is to study an intervention or treatment. In this study all patients with PCT will be given a standard dose of Harvoni and monitored for two years. Currently there are two standard therapies for PCT, phlebotomies (removing certain amounts of blood ...

Phase

Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda

Study Design: Pragmatic Interventional study Primary Study Objective: To determine and compare time to remission with treatment with low-dose hydroxychloroquine or repeated phlebotomy in participants with PCT. Secondary Study Objective(s): To assess the effects of susceptibility factors on responses to treatment of PCT by these methods. To determine and compare ...

Phase

Clinical Diagnosis of Acute Porphyria

The porphyrias are a group of genetic diseases caused by disturbances in the formation of heme, an essential component of hemoglobin and other proteins, leading to either acute (neurologic) and/or chronic (cutaneous) symptoms. Acute porphyria is often difficult to diagnose because symptoms may not be specific and, unless the patient ...

Phase N/A

Panhematin for Prevention of Acute Attacks of Porphyria

This is a double-blind, randomized, placebo-controlled, parallel group trial investigating the efficacy and safety of Panhematin for preventing acute attacks in at least 20 patients with well-documented acute porphyria (acute intermittent porphyria, hereditary coproporphyria or variegate porphyria). These patients will (1.) have had frequent attacks in the past, with symptoms ...

Phase

A Study to Investigate the Interaction Between Givosiran and a 5-probe Drug Cocktail in Patients With Acute Intermittent Porphyria (AIP)

The purpose of this study is to evaluate the effect of givosiran on the pharmacokinetics of the 5-probe cocktail of midazolam, caffeine, losartan, omeprazole, and dextromethorphan, and their metabolites, in asymptomatic patients with Acute Intermittent Porphyria.

Phase

INSIGHT-AHP: A Study to Characterize the Prevalence of Acute Hepatic Porphyria (AHP) in Patients With Clinical Presentation and History Consistent With AHP

This study will use specific diagnostic tests on a group of patients who are experiencing symptoms typical of acute hepatic porphyria (AHP) to determine how many have the condition, and to potentially help improve the diagnostic process for patients in the future.

Phase N/A