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Hernia Clinical Trials

A listing of Hernia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (16) clinical trials

Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen

This is a double-blind randomized trial of intravaginal estrogen (conjugated estrogens, 0.625mg/1g cream) vs. placebo in postmenopausal women (n=222 total) with symptomatic prolapse beyond the hymen planning transvaginal native tissue repairs. Medication will be started 6-8 weeks before surgery and continued for 1 year postoperatively, i.e. until scar remodeling is ...

Phase

Heavy Weight Versus Medium Weight Mesh in Ventral Hernia Repair

Approximately five million laparotomies are performed annually in the United States with upwards of 25% of these patients developing a ventral hernia postoperatively. Despite the prevalence of ventral hernias, the surgical approach to these procedures lacks standardization. In fact, nearly 20%-50% of patients undergoing ventral hernia repair (VHR) will experience ...

Phase

Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction

This is a prospective, randomized-controlled trial comparing two porcine acellular matrices in abdominal wall reconstruction. It is single-blind (patients are blinded to the type of mesh used while surgeons are not). Our goals in this study are: PRIMARY OUTCOME: To compare the overall complication rates between two non-cross-linked porcine dermal ...

Phase

Prevalence of Port Site Hernia After Mesh Placement in Laparoscopic Cholecystectomy.

Randomized controlled trial. Patients with more than two incisional hernia risk factors (age 70, BMI 30, diabetes mellitus, fascial enlargement) who undergo elective/emergent cholecystectomy. Control arm: fascial closure with simple PDS 2/0 Stitches. Study arm: fascial closure with simple PDS 2/0 stitches and onlay polypropylene mesh placement. Main outcome umbilical ...

Phase

Hernia Surgery Urinary Retention

The purpose of this study will be to investigate whether pre-operative treatment with a selective alpha1-adrenoceptor antagonist affects the likelihood of male patients developing post-operative urinary retention following hernia repair surgery. It is also of interest to determine whether or not a well-known urological screening tool, the IPSS, can identify ...

Phase

Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair

To assess effect of local anesthetic into the preperitoneal space during laparoscopic hernia repair on post-operative pain.

Phase

Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia

Patients will be randomized to either a synthetic (light weight synthetic or biologic (small intestinal submucosa [SIS]) mesh group. Endpoints will be measured up to 5 years for the study as a whole, at 6 months and at 60 months. Prior to and following laparoscopic paraesophageal hernia repair, patients will ...

Phase

PROPHYlactic Implantation of BIOlogic Mesh in Peritonitis (PROPHYBIOM)

To evaluate the efficacy of the use of swine dermal collagen prosthesis implanted preperitoneally as a prophylactic procedure against incisional hernia in patients operated in urgency/emergency setting in contaminated/infected fields with peritonitis. The aim of the study is to reduce the incidence of incisional hernia from 50% to 20%.

Phase

Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh

Experimental: Reinforcement with Absorbable Mesh Closure of the ileostomy closure incision is reinforced with insertion of a rectangular segment (1 cm wide and the length corresponding to the incision) of a prosthetic commercially available GORE BIO-A Tissue Reinforcement prosthesis (W. L. Gore & Associates, Flagstaff, Arizona, USA) mesh. The BIO-A ...

Phase

A Longitudinal Prospective Outcomes Study of Laparoscopic Abdominal Wall Hernia Repair Using Symbotex Composite Mesh

This study is being done to validate the efficacy of Symbotex™ as an effective synthetic mesh option in the repair of grade I and II ventral hernias. It will also set the groundwork for a future clinical trial in which the efficacy of Symbotex® can be compared to other synthetic ...

Phase