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Acute Myeloid Leukemia Clinical Trials

A listing of Acute Myeloid Leukemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (60) clinical trials

A clinical trial to evaluate treatments for patients with Acute myeloid leukemia

Study Groups: If you are found to be eligible to take part in this study, you will be assigned to a study group based on when you joined the study. Up to 6 groups of 3-6 participants will be enrolled in the dose escalation part of the study. Up to ...


Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM)

To make donor derived multiTAA-specific T cells, the investigators will collect blood from the patient's stem cell donor, and mix the donor's T cells with small pieces of tumor proteins WT1, PRAME, NY-ESO-1, and Survivin. These protein fragments stimulate the donor T cells to grow and react against these proteins ...


Timed Sequential Busulfan and Post Transplant Cyclophosphamide for Allogeneic Transplantation

Study Groups: You will be assigned to 1 of 4 study groups, depending on what type of stem cells you will receive, your age, diagnosis, and health status. Groups 1 and 3 will receive stem cells from a haploidentical donor (a donor that is a half match of yours). You ...


Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

This is a Phase1/2 dose escalation study evaluating the safety and feasibility of BPX-501 infused after partially mismatched, related (haploidentical), T cell-depleted HSCT. The purpose of this clinical trial is to determine whether BPX-501 infusion can facilitate engraftment, enhance immune reconstitution and potentially improve the graft versus leukemia (GVL) effect, ...


A clinical trial seeking patients for a research study for the treatment of Myelodysplastic Syndrome With Excess Blasts-2, Acute myeloid leukemia, Adult Myelodysplastic Syndrome, Untreated Adult Acute Myeloid Leukemia

PRIMARY OBJECTIVES: I. To select, based on overall survival, any or all of the "Novel Therapeutic" regimens for further testing against azacitidine in patients age 60 and older with newly diagnosed acute myeloid leukemia (AML) or myelodysplastic syndrome with excessive blasts-2 (MDS-EB-2). (Phase II) II. To compare overall survival of ...


A clinical trial seeking patients for a research study for the treatment of Recurrent Adult Acute Myeloid Leukemia, Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Recurrent Hodgkin Lymphoma, Hematopoietic Cell Transplantation Recipient, Recurrent Adult Acute Lymphoblastic Leukemia, Previously Treated Myelodysplastic Syndrome, Recurrent Non-Hodgkin Lymphoma, MYELODYSPLASTIC SYNDROME, MYELOPROLIFERATIVE DISORDER, Preleukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Plasma Cell Myeloma

PRIMARY OBJECTIVES: I. To determine the maximum-tolerated dose (MTD) of ipilimumab or nivolumab administered to patients with relapsed hematologic malignancies following allogeneic stem cell transplantation. (Phase I) II. To characterize the toxicity of ipilimumab or nivolumab administered at the MTD in this patient population. (Phase Ib) SECONDARY OBJECTIVES: I. To ...


A clinical trial sponsored by National Cancer Institute (NCI) for a research study for the treatment of Acute myeloid leukemia, Untreated Adult Acute Myeloid Leukemia

PRIMARY OBJECTIVES: I. To evaluate the negative predictive value (NPV) of post-treatment FLT PET/CT imaging for complete remission (CR) in patients receiving induction chemotherapy for acute myeloid leukemia (AML). SECONDARY OBJECTIVES: I. To evaluate the positive predictive value (PPV) of post-treatment FLT PET/CT imaging for complete remission. II. To estimate ...


Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR

This open label two-step phase II study is designed to determine the safety and efficacy of epigenetic priming with 5-Azacytidine immediately prior to reduced intensity conditioning for an in vivo T-cell depleted hematopoietic stem cell transplantation for high risk myeloid malignancies in complete remission (CR). Subjects will be given a ...


Patients are needed to participate in a clinical research study of Anti-thymocyte globulin, Bone marrow transplant from a related donor, Tacrolimus

The induction of transplantation tolerance involves the specific elimination of the immune response to the transplant but not to other antigens. In the realm of kidney transplantation, tolerance means that the recipient is unable to detect the donor transplant kidney as foreign, and therefore the recipient is unable to reject ...

Phase N/A

Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Lymphocytic or Myelogenous Leukemia

PRIMARY OBJECTIVES: I. Following a patient safety lead-in, evaluate the anti-tumor activity of the allogeneic hematopoietic cell transplant (alloHCT) preparative regimen - TMLI, cyclophosphamide (Cy) and etoposide (VP-16), as assessed by 2-year progression-free survival (PFS). SECONDARY OBJECTIVES: I. Estimate overall survival (OS), cumulative incidence (CI) of relapse/progression, and non-relapse mortality ...