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Alcohol Dependence Clinical Trials

A listing of Alcohol Dependence medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (36) clinical trials

A Phase II, Randomized, Double-blind Study to Evaluate Efficacy, Safety, and Tolerablity of ALKS 3831 in Subjects with Schizophrenia with Alcohol Use Disorder

Phase

Lifestyle Physical Activity Intervention for Depressed Alcohol Dependent Women

Alcohol use disorders (AUDs) are the 3rd leading preventable cause of death in the U.S. and are associated with significant economic burden and health-related negative consequences. While women may be less likely to develop AUDs, they experience more significant negative health consequences of alcohol use than men. Due to stigma, ...

Phase

Testing Doxazosin to Treat Stress Mechanisms in Alcoholism

OBJECTIVES To translate the preclinical evidence from animal models to stress-induced relapse in humans via direct pharmacological antagonism of the noradrenergic system in abstinent alcoholics with doxazosin, an alpha1 noradrenergic receptor blocker. To screen the efficacy of doxazosin to target stress-related relapse mechanisms in abstinent alcoholics as a cost-effective first ...

Phase

A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence

Two to four sites will participate in this study. Aims of the study are 1) to characterize the acute effects of PO psilocybin 25 mg/70 kg, 30 mg/70 kg, and 40 mg/70 kg in alcohol dependent patients; 2) to evaluate the effect of psilocybin treatment on drinking outcomes for 32 ...

Phase

Combining Varenicline and Naltrexone for Smoking Cessation

This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for smoking cessation in a sample of heavy drinking ...

Phase

Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence

This is a randomized, controlled trial with 50 veterans diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence. Veterans will be randomized to receive either zonisamide (400 mg) or placebo for 12 weeks in a double blind fashion. Randomization will be done using 3:1 ratio and will be performed ...

Phase

Gabapentin for Bipolar & Cannabis Use Disorders

Bipolar disorder (BD) is the Axis I condition most strongly associated with cannabis use disorder (CUD); there is a six-fold increase in the prevalence of CUD in individuals with BD relative to the general population. Individuals with co-occurring CUD and BD (CUD+BD) have substantially worse clinical outcomes than those with ...

Phase

Cannabidiol and Cocaine Craving/Dependence

The investigators will carry out a double-blind, randomized, parallel-group, placebo-controlled trial to assess the effects of 92 days of CBD 400 mg (for the first 2 days starting on Day 2 of the study) or 800 mg (subjects who report side effects with the 800mg dose will be administered the ...

Phase

Bilateral Prefrontal Modulation in Alcoholism

Before (baseline) and after tDCS or sham-tDCS treatment, subjects will be examined: clinically, regarding craving (obsessive compulsive scale), depressive (Hamilton depression rating scale) and anxiety (Hamilton anxiety rating scale) symptoms and quality of life of the World Health Organization (WHOQOL-BREF); cognitively, regarding frontal (Frontal assessment battery), mental state (mini-mental status ...

Phase

Bilateral Prefrontal Modulation in Crack-cocaine Addiction

Before (baseline) and after tDCS or sham-tDCS treatment, subjects will be examined: clinically, regarding craving (obsessive compulsive scale), depressive (Hamilton depression rating scale) and anxiety (Hamilton anxiety rating scale) symptoms and quality of life of the World Health Organization (WHOQOL-BREF); cognitively, regarding frontal (Frontal assessment battery), mental state (mini-mental status ...

Phase