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Dry Eye Disease Clinical Trials

A listing of Dry Eye Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (58) clinical trials

Ocular Surface Microbiome in Dry Eye Patients

The ocular surface is the first line of defense of the eye, it is therefore where external threats are sensed, and potential insults neutralised. Over the course of evolution, various microbes, especially bacteriae, have come to colonise the ocular surface as commensals. The commensals have a role to maintain the ...

Phase N/A

Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome

Dry eye syndrome is a highly prevalent ocular disease with an increasing incidence in the elderly population. Topically administered lubricants are the basis for treatment of this disease. However, exact information about influence on tear film thickness and corneal residence time of topical lubricants is still sparse, therefore no ideal ...


Ocular Surface Disease in Chronic Graft-Versus-Host Disease (GVHD) Patients

Dry eye is a multi-factorial disease that is frequently encountered in ophthalmological practice. Common dry eye symptoms include eye irritation, heaviness of the eyelids, blurred vision and light sensitivity (1). The worldwide prevalence of dry eye is generally high (2-4). In Asia, dry eye may affect up to 22% of ...

Phase N/A

Closed Eye Neutrophils in Dry Eye Disease

Every night during sleep, there is an influx of white blood cells on to the surface of the eye. These cells likely perform a protective function, but it is also possible that their dysregulation could lead to disease. Using a larger cohort, our investigation hopes to better understand the function ...

Phase N/A

An 8-week Study to Evaluate Safety and Efficacy of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drops Solution Versus Vehicle in Patients With Dry Eye

The proposed phase II study is a single-center, randomized, double-masked, parallel-arm, vehicle-controlled trial, designed to evaluate the safety and efficacy of Recombinant Human Nerve Growth Factor (rhNGF) eye drops at 20 g/ml concentration administered six times daily for 8 weeks in patients with dry eye. After confirmation of inclusion and ...


rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host Disease

The purpose of this study is to evaluate the tolerability and preliminary efficacy of rhDNase I eye drops in patients with ocular Graft-vs.-Host disease (oGVHD).


Effect of IKERVIS Eye Drops Once Daily on the Quality of Vision in Dry Eye Disease Patients With Severe Keratitis

In this phase IV clinical trial the Month 3 visit assessments will be used to assess the efficacy (quality of vision and other parameters) and safety of IKERVIS in DED patients with severe keratitis. To assess the effect on the quality of vision of IKERVIS (1mg/ml ciclosporin) eye drops administered ...


Laser Acupuncture for Dry Eye

Objective: Dry eye is a common ophthalmologic disorder causing ocular discomfort in daily life. The investigators aim to investigate the effects of laser acupuncture therapy for patients with dry eye. Methods: 200 subjects with dry eye are enrolled at two ophthalmic centers and randomly assigned to a laser acupuncture group ...

Phase N/A

Optive Brand For Day And Night Dry Eye Management

This is an open label study of Optive eyedrops and gel combination for day and night dry eye management

Phase N/A

Study to Evaluate the Efficacy and Safety of CKD-350

Active controlled, randomized, double-blind, multi-center, phase 3 trial to evaluate the efficacy and safety of CKD-350 eye drops in patients with dry eye syndrome