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Liver Failure Clinical Trials

A listing of Liver Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (91) clinical trials

Normothermic Liver Preservation Trial

The standard approach for storage and transportation of livers for transplantation involves cold perfusion with Histidine-tryptophan-ketoglutarate (HTK) or alternative solutions, and storage in sterile bags surrounded by preservation solution in a box by ice. The prolonged cold ischemic injury substantially compounds pre-existing donor liver graft injury, further exacerbating potential risk ...

Phase

The Relationship of Initial Liver Profile and Outcome After Transplantation

Study population Tissue from all deceased adult liver transplant grafts will be collected. The test samples will be selected from procedures were the liver transplant recipient has developed IC. The control samples will include tissues from procedures were the transplant recipient had an uncomplicated outcome. There will be matching of ...

Phase N/A

13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF

The importance of identifying the patient with with ALI or ALF who is likely to die without a liver transplant cannot be overstated and has remained a primary focus of clinical investigation for 25 years. A recent analysis also conducted by the Acute Liver Failure Study Group (ALFSG) found that ...

Phase

Better Diagnostic Tools for Children and Adolescents With Acute Liver Failure and Chronic Liver Insufficiency

Research question: Liver disease in childhood and adolescence can present as chronic liver disease (CLD) or acute liver failure (ALF), with different interim stages, and with the possibility of a presentation with acute on chronic liver failure as well. At the department of Pediatrics at Rigshospitalet the investigators follow around ...

Phase N/A

The Role and Dynamics of Liver Dysfunction in Patients Undergoing Cardiac Surgery

Prospective, consecutive study of patients undergoing cardiac surgery in Heart and Vascular Center, Semmelweis University, Budapest. Registered data: Anamnestic and demographic data Liver dysfunction prior surgery, etiology of liver dysfunction Perioperative clinical data: laboratory tests, imaging, haemodynamic measures risk prediction score of the American Society of Anesthesiologists(ASA), EUROpean System for ...

Phase N/A

Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury

This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. This echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. The primary endpoint is to describe ...

Phase N/A

Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study

This International-European, investigator-initiated, multicenter, prospective, observational study will be performed in centers that belong to the European Foundation for the Study of Chronic Liver failure (EF-CLIF)-European Association for Study of the Liver (EASL)-EASL-CLIF Consortium. The population of patients would include ca. 1,200 cirrhotic patients over a twelve-months period. These patients ...

Phase N/A

A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China

Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and provides a global assessment of coagulation incorporating the cumulative effect of the interactions at various levels between plasma components and cellular component of coagulation. And through ...

Phase N/A

SVC and Its Relationship to CVP Measurements in Liver Transplantation

Central venous pressure (CVP) measured invasively through a central venous catheter in the internal jugular vein or through a right atrial port of a pulmonary artery catheter is commonly used during liver transplant surgery. CVP measurements at the SVC-RA junction are a function of circulating blood volume, right ventricle function, ...

Phase N/A

Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection

Background. With a reported incidence of up to 70%, liver failure is the most frequent complication necessitating intensive care and prolonging hospital stay. Animal studies suggest that the glycogen content of the liver is a key regulator of liver function and that glycogen depletion, a mandatory consequence of preoperative fasting, ...

Phase N/A