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Lymphoproliferative disorders Clinical Trials

A listing of Lymphoproliferative disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (23) clinical trials

Chidamide Combined With R-GDP in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

The treatment outcome of patients with relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL) are not satisfactory especially for those not suitable for transplantation. One of main reason is chemotherapy resistance. The investigators conducted this study to evaluate the efficacy of Chidamide combined with R-GDP(rituximab/gemcitabine/dexamethasone/cisplatin) in treating patients with relapsed ...

Phase

Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases

This study is performed in order to investigate the molecular mechanisms of action of photo(chemo)therapy in skin diseases, including psoriasis, cutaneous T-cell lymphoma, other lymphoproliferative disorders of the skin, eczema, lichen planus, prurigo/pruritus, polymorphic light eruption, mastocytosis, graft-versus-host disease, vitiligo and other photo(chemo)therapy-responsive diseases. Twenty patients will be enrolled per ...

Phase N/A

Registry of Older Patients With Cancer

OBJECTIVES Primary To create a registry (to be called "Carolina Senior") of older patients with an appointment at North Carolina Cancer Hospital. To have these patients complete a Geriatric Assessment (GA). Secondary To measure the response rates of GAs of Carolina Senior patients and their satisfaction with a GA by ...

Phase N/A

Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies

Patients who participate will be asked to complete detailed family and medical history questionnaires initially, with a follow-up questionnaire every year. Patients will be asked to supply a blood sample and possibly a mouthwash sample, both of which can be done by mail. Patients will be asked to consent to ...

Phase N/A

Plerixafor Harvesting And No Chemotherapy for Transplantation of Autologous STem Cells In Cancer (PHANTASTIC)

To assess the efficacy and toxicity of plerixafor (AMD 3100) together with granulocyte-colony stimulating factor (G-CSF) for stem cell mobilisation, in patients with myeloma or lymphoma requiring high dose chemotherapy with stem cell rescue.

Phase N/A

Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV-Associated Malignancies

This is a Phase II trial to evaluate the efficacy and safety of human leukocyte antigen (HLA) partially-matched third-party allogeneic Epstein-Barr virus cytotoxic T lymphocytes (EBV-CTLs) for the treatment of EBV-induced lymphomas and EBV-associated malignancies.

Phase

Erythropoietic Protoporphyrias: Studies of the Natural History Genotype-Phenotype Correlations and Psychosocial Impact

The porphyrias are a group of rare metabolic diseases that may present in childhood or adult life and are due to deficiencies of enzymes in the heme biosynthetic pathway. The most common manifestations are related to accumulation of intermediates in the pathway and usually occur as acute neurological attacks (as ...

Phase N/A

Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

Phase

3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer

OBJECTIVES Primary Evaluate the use of 3'-deoxy-3'-[18F] fluorothymidine (FLT) positron emission tomography (PET) imaging to measure tumor proliferation and the DNA synthetic pathway (thymidine kinase levels) in patients with cancer. Secondary Determine the efficacy of FLT PET imaging in detecting lesions and estimating response to treatment. OUTLINE: Patients undergo up ...

Phase N/A

Cytotoxic T-Lymphocytes for EBV-positive Lymphoma GRALE

Subjects (or their syngeneic donor) will give blood for investigators to make LMP/BARF1/EBNA-1 (GRALE) CTLs in the lab. These cells will be grown and frozen for the subject. Patients will be started on the lowest dose (1 of 3 different levels) of GRALE T cells. Once that dose schedule proves ...

Phase