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Precancerous condition Clinical Trials

A listing of Precancerous condition medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (19) clinical trials

Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Patients and Healthy Participants Undergoing Colonoscopy Endoscopy or Surgery

OBJECTIVES: - Identify new potential biomarkers of increased gastrointestinal cancer risk using tissue and biofluid samples from patients and healthy volunteers undergoing colonoscopy, endoscopy, or surgery. - Develop new screening strategies based on substances found in tissue and biofluid samples. OUTLINE: This is a multicenter study. Patients and healthy volunteers ...

Phase N/A

Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer Head and Neck Cancer or Aerodigestive Tract Cancer and in Normal Volunteers

OBJECTIVES: Primary - Determine intermediate biomarkers of premalignant respiratory epithelial lesions, such as genetic mutations or altered growth factor expression, in patients with dysplasia of the respiratory epithelium or lung cancer, head and neck cancer, or aerodigestive tract cancer. Secondary - Establish a tissue repository of normal and dysplastic respiratory ...

Phase N/A

Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus

OBJECTIVES: - To determine the clinical feasibility of obtaining endoscopic esophageal images using a tethered capsule endoscope (TCE). (Phase I) - To determine the optimal weight and possibly shape for rapid patient ingestion and extraction of the TCE. (Phase I) - To determine the optimal tether design (e.g., rigidity, distance ...

Phase

Genetic and Clinical Study of Patients With Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

OBJECTIVES: - Identify patients or confirm suspected cases of xeroderma pigmentosum (XP), Cockayne syndrome (CS), XP/CS, or trichothiodystrophy (TTD). - Document presence or absence of cancers (skin, eye, tongue, or internal) in these patients. - Document atypical features or unusual environmental exposures of these patients. - Examine tissue (skin, blood, ...

Phase N/A

Biological Therapy and Combination Chemotherapy in Treating Patients With Lymphomatoid Granulomatosis

OBJECTIVES: - Determine the long-term efficacy of interferon alfa in patients with lymphomatoid granulomatosis. - Determine the long-term efficacy of etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab in patients with grade III lymphomatoid granulomatosis OR in patients who fail interferon therapy. - Determine the response in patients treated with these ...

Phase

Collecting Tissue Samples From Patients With Melanocytic Nevi or Pigmented Lesions

OBJECTIVES: Primary - Obtain tissue from benign melanocytic nevi and LCMN for experimental study. - Refine culture and immortalization methods for melanocytes derived from melanocytic nevi that permits in vitro expansion of these cells for functional study. - Correlate clinical and dermoscopic observations of primary melanoma with histopathology to establish ...

Phase N/A

Study of Patients With Cancer or Precancerous Conditions

OBJECTIVES: - To follow and evaluate patients, longitudinally with cancer or precancerous conditions referred to the NIH Clinical Center Pediatric Oncology Branch who present with disease manifestations that lend themselves to clinical evaluation and are of unique scientific importance. - To allow, when clinically indicated, patients to receive standard care ...

Phase N/A

Studying Genes for Barrett's Esophagus in Brothers and Sisters

OBJECTIVES: Primary - To investigate the familial incidence of heartburn and Barrett's esophagus in first and second degree relatives of patients with Barrett's esophagus in the United Kingdom. - To determine susceptibility genes for Barrett's esophagus in affected sibling pairs. - To examine gene-environment interactions, such as smoking, alcohol, and ...

Phase N/A

Biomarkers in Women at High Risk for Developing Cervical Cancer

OBJECTIVES: - Assess biomarkers of risk for progressive cervical neoplasia that can distinguish patients at highest risk for cervical cancers from patients with benign infection. - Develop a comprehensive list of potential risk biomarkers by examining cervical tissues of women with normal, human papilloma virus (HPV) infection, precancer, and cancer. ...

Phase N/A

Sunitinib in Treating Patients With Recurrent or Unresectable Meningioma Intracranial Hemangiopericytoma or Intracranial Hemangioblastoma

OBJECTIVES: Primary - To evaluate the activity of sunitinib malate in patients with recurrent meningioma as measured by 6-month progression-free survival. Secondary - To describe the response rate, median time-to-progression, and overall survival in these patient. - To evaluate the safety of sunitinib malate in patients with recurrent meningioma. Exploratory ...

Phase