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Deafness Clinical Trials

A listing of Deafness medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (32) clinical trials

Alport Syndrome Treatments and Outcomes Registry

Detailed Description: ASTOR is envisioned as a permanent organization sustained by private philanthropic and public funding sources. Recruitment of participants for the registry will consist of three approaches. First, pediatric nephrologists in the United States and Canada will be invited to participate in ASTOR. Activities of participating investigators will include ...

Phase N/A

Carrier Frequency of a Recurring Mutation Causing Recessive Type VIII Osteogenesis Imperfecta in African-Americans and Contemporary West Africans

Classical osteogenesis imperfecta (OI), or brittle bone disease , is a well described autosomal dominant bone dysplasia caused by mutations in the genes encoding type I collagen, the major protein of bone matrix. However, genetic testing has shown that 10-15% of clinical OI is not caused by collagen defects. Furthermore, ...

Phase N/A

Clinical Evaluation of the Cochlear Nucleus CI532 Cochlear Implant in Adults

Appropriate candidates will receive a CI532 cochlear implant and be fit with the CP1000 sound processor. Imaging will be completed pre-op, intra-op, and post-op to assess implant location. Speech perception testing as well as subjective questionnaires will be administered over 12 months.

Phase N/A

A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL

This international, multi-center, Phase 2/3 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with Alport syndrome. The Phase 2 portion of the trial will be open-label and enroll up to 30 patients. The Phase 3 portion of the trial will be double-blind, randomized, placebo-controlled ...


Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta

Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss. It is seen in both genders and all races. OI can range from very severe to ...


Clinical Performance of a New Implant System for Bone Conduction Hearing

To study the initial experience with implanting and fitting the new Bone conduction system in patients with conductive, mixed or Single sided Sensorineural deafness.

Phase N/A

A Study in Adult Patients With Type I III or IV Osteogenesis Imperfecta Treated With BPS804

The purpose of this study is to select a suitable dose of BPS804 by comparing it with a dummy treatment and measuring the strength/quality of bone using a special type of CT scanner. Participants will be treated for 1 year.


An Exploratory Study of BPS804 Treatment in Adult Patients With Type I III or IV Osteogenesis Imperfecta

The purpose of this study is to investigate the effect of BPS804 on strength/quality of bone in patients with Type I, III or IV Osteogenesis imperfecta using a special type of CT scanner. Participants will be treated for 1 year.


Clinical Survey of Minimally Invasive Ponto Surgical Technique (MIPS)

The objective of the study is to compare the outcomes after a surgical procedure with minimally invasive Ponto surgery (MIPS, test group) and tissue preservation surgery (control) for placing Oticon Medical Ponto implants and abutments.

Phase N/A

An Observational/Natural History Study of Cockayne Syndrome

This is an Observational Study of pediatric patients diagnosed with Cockayne Syndrome (CS) to assess the natural progression of that disease, with special attention to hearing and physical changes in length or height, weight, head circumference, and arm span during "standard-of-care" treatment. A portion of this information will be collected ...

Phase N/A