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Deafness Clinical Trials

A listing of Deafness medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (22) clinical trials

Alport Syndrome Treatments and Outcomes Registry

Detailed Description: ASTOR is envisioned as a permanent organization sustained by private philanthropic and public funding sources. Recruitment of participants for the registry will consist of three approaches. First, pediatric nephrologists in the United States and Canada will be invited to participate in ASTOR. Activities of participating investigators will include ...

Phase N/A

European Alport Therapy Registry - European Initiative Towards Delaying Renal Failure in Alport Syndrome

Early diagnosis in children with Alport syndrome (AS) with isolated hematuria opens a "window of opportunity" for early intervention. Currently there are no causal therapeutic options which are proven to delay renal failure in AS. ACE-inhibition (ACEi) has been shown to reduce proteinuria in Alport patients and to delay renal ...

Phase N/A

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination of selected patients with XP, XP/CS, CS, or TTD and follow their clinical course. We ...

Phase N/A

Natural History Pathogenesis and Outcome of Autoinflammatory Diseases (NOMID/CAPS DIRA CANDLE SAVI NLRC4-MAS Still'S-like Diseases and Other Undifferentiated Autoinflammatory Diseases)

Autoinflammatory diseases are a group of immune dysregulatory diseases that are characterized by recurrent episodes of systemic inflammation as well as organ-specific inflammation that can involve the skin, eyes, joints, bones, muscles, lungs, serosal surfaces, inner ear, brain, and other organs. The prominent role of IL-1 in the pathogenesis of ...

Phase N/A

Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts

Nonsyndromic hereditary hearing impairment is a genetically heterogeneous disorder that can be caused by mutations in any one of at least 60 different genes. Enlargement of the vestibular aqueduct (EVA) is a radiologic finding known to be associated with mutations in one of these genes, the Pendred syndrome gene (SLC26A4, ...

Phase N/A

Genetic Studies of Strabismus Congenital Cranial Dysinnervation Disorders (CCDDs) and Their Associated Anomalies

If left untreated or unrecognized, strabismus or misalignment of the eyes, can impair the development of normal vision and is recognized to be an inherited trait in some families. The Engle Lab has investigated the genetics of complex and common strabismus and eyelid movement disorders for over 10 years and ...

Phase N/A

Dental Malocclusion and Craniofacial Development in OI

Investigators will look at dental health in people with OI and will describe teeth misalignment and head and neck defects in individuals with moderate to severe Osteogenesis Imperfecta (OI). Investigators will look at results from the Longitudinal study of OI to complete the study evaluations. Several x-rays will be performed ...

Phase N/A

BBD Longitudinal Study of Osteogenesis Imperfecta

The purpose of this natural history study is to perform a long-term follow-up of a large group of people with osteogenesis imperfecta (OI). We will collect information including: medical history number of broken bones, surgeries done medications taken, ability to walk, pain lung function and breathing hearing bone mineral density ...

Phase N/A

Urinary Biomarkers of OI Pathobiology

Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss. It is seen in both genders and all races. OI can range from very severe to ...

Phase N/A

Long QT and Hearing Loss Registry

The purpose of this study is to determine the true incidence of long QT (LQT) amongst a large cohort of subjects diagnosed with unilateral (right/left) or bilateral sensorineural hearing loss. The goal of this study is to answer the following questions: What is the incidence of an abnormal ECG (QTc ...

Phase N/A