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Bone Diseases Clinical Trials

A listing of Bone Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (78) clinical trials

Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia

PRIMARY OBJECTIVES: I. Determine the safety profile of alisertib in patients with acute megakaryoblastic leukemia (AMKL) and in patients with myelofibrosis (MF). SECONDARY OBJECTIVES: I. Determine preliminary efficacy of alisertib in both populations. TERCIARY OBJECTIVES: I. Describe pharmacodynamics (PD) effects of alisertib in peripheral blood and/or bone marrow samples. II. ...

Phase N/A

BonyPid-500TM Bone Graft Substitute Study

This is a pilot, randomized, single-blind, two arm controlled, multicenter study in subjects undergoing surgical treatment for peri-implantitis disease. Eligible subjects will undergo a surgical treatment and be randomly assigned during surgical intervention (after flap opening) in a 1:1 ratio to adjunct BonyPid-500TM implantation or no BonyPid-500TM implantation. Randomization will ...

Phase N/A

Bone Level Tapered Multi-Center Study

The primary objective is to demonstrate that the change in mean peri-implant marginal bone level changes (mesial and distal) from loading to 12 months post-loading of the test treatment will not be worse than the control treatments. The secondary objectives of the study are to assess differences in clinical and ...

Phase N/A

Omics4Aging: Stratification of Frailty Population

This exploratory study will investigate ways to better characterize the frailty phenotype by a combination of i) geriatric assessment (here only: frailty criteria according to Fried), ii) clinical surrogate markers (including those of inflammation), iii) body composition, iv) nutritional profiling, v) metabolite profiling using a metabolomics approaches.

Phase N/A

Changes in Biochemical Markers of Bone Turnover (Serum CTX and PlNP) After Initiation of a "Drug Holiday" From Bisphosphonates

Bisphosphonates (BP) are widely used in the prevention and treatment of osteoporosis in postmenopausal women and older men. Recently, there has been concern about the risk of adverse events after several years of using these agents. This has resulted in a publication from the Food and Drug Administration that suggested ...

Phase N/A

Calcium Phosphate Cement Registry (CPC Registry)

The objective of this observational prospective study is to collect safety and performance data relating to the use of injectable Calcium Phosphate Cements "GRAFTYS®HBS/GRAFTYS®Quickset (or their private labels)" in routine clinical practice from various international hospitals. Therefore this observational study will allow to support data about risk management (established at ...

Phase N/A

The Influence of Mucosal Tissue Thickness on Soft and Hard Tissue Changes Around Implants

The objectives of this clinical study are; - to evaluate the influence of mucosal tissue thickness on periimplant soft and hard tissue changes. - to evaluate whether acellular dermal matrix (ADM) derived allogenic membrane or subepithelial connective tissue grafts performed at implant placement could be effective in vertical soft tissue ...

Phase N/A

Interbody Spacers With map3 Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion

Map3 is an allogeneic bone matrix which also contains demineralized cortical cancellous bone and multipotent adult progenitor cells (MAPC). MAPC-based cells are derived from allograft bone marrow, isolated from other cells and cryopreserved. Both the scaffold and cellular constituents are processed from the same donor but are provided in separate ...

Phase N/A

HIV UPBEAT: Understanding the Pathology of Bone Disease in HIV-infected Patients.

This study will follow HIV positive and negative subjects annually for 5 years. The aims of this study include: - to describe the pathology underlying low bone mineral density - to assess the relationship between low bone mineral density and antiretroviral therapy exposure - to assess the relationship between low ...

Phase N/A