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Melanoma Clinical Trials

A listing of Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (290) clinical trials

Treatment of a Resistant Disease Using Decitabine Combined With Vemurafenib Plus Cobimetinib

Primary Objectives Evaluate the safety and tolerability of the proposed schedule of decitabine and Vemurafenib plus Cobimetinib in the treatment of metastatic melanoma. Assess tumor response rates by RECIST criteria Secondary Objectives To measure the time to progression of patients treated with this combination in comparison to patients treated historically ...

Phase

Circulating Melanoma Cells in Metastatic Patients Treated With Selective BRAF Inhibitors

This is an observational prospective pilot study aimed to investigate the association between changes of total and apoptotic CMC count and disease progression in MM patients undergoing treatment with selective inhibitors of mutated B-RAF.

Phase N/A

To Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors

ABI-007-PST-001 is a Phase 1 / 2, multicenter, open-label, dose-finding study to assess the safety , tolerability, and preliminary efficacy of weekly nab-paclitaxel in pediatric patients with recurrent or refractory solid tumors (excluding brain tumors). The Phase 1 portion of the study, with a dose escalation design, ended and the ...

Phase

Collecting Tissue Samples From Patients With Melanocytic Nevi or Pigmented Lesions

OBJECTIVES: Primary - Obtain tissue from benign melanocytic nevi and LCMN for experimental study. - Refine culture and immortalization methods for melanocytes derived from melanocytic nevi that permits in vitro expansion of these cells for functional study. - Correlate clinical and dermoscopic observations of primary melanoma with histopathology to establish ...

Phase N/A

Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma

Leptomeningeal Disease: (Cohort D): Study Visits: You are expected to stay in the Houston area for at least 21 days in order to take part in this study. During this study, you will have the following tests and procedures: - You will have an MRI of the complete spine and ...

Phase

Family Study of Melanoma in Italy

To date 557 subjects, including cases of melanoma and unaffected relatives, have been recruited in the family study of melanoma at the Bufalini Hospital, Cesena, Italy, University ofl'Aquila, L'Aquila, Italy, and the Istituto Valenciano de Oncologia, Valencia, Spain. Clinical characteristics of melanoma in the families studied were similar to those ...

Phase N/A

Cytogenetic Study of Ocular Melanoma

The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.

Phase N/A

Optical Coherence Tomography of Retinal Abnormalities Associated With Choroidal Nevus Choroidal Melanoma and Choroidal Melanoma Treated With Iodine-125 Brachytherapy

During regularly scheduled appointments, Optical Coherence Tomography (OCT) is performed on consented subjects. The OCT is a new type of camera that takes very detailed pictures inside of the eye and deeper into eye tissues. Optical Coherence Tomography imaging of intraocular tumors may lead to improved diagnosis and monitoring of ...

Phase N/A

Characterization of the Melanoma-Specific Immune Response

The aim of the study is to in-vitro characterize and expand T cells specific for melanoma-derived antigens. Peripheral blood with be collected from 20 volunteers with biopsy proven melanoma and 10 age matched controls. Blood will be collected prior to the initiation of chemotherapy. There will be no more than ...

Phase

Investigate the Diagnostic Value and Possibilities of OCT in Non-Melanoma Skin Cancer.

Optimal management of skin malignancies relies on early and accurate diagnosis. The reference standard in skin cancer is biopsy and histopathological assessment from a clinical suspicious skin lesion. The clinical diagnosis of skin cancer has sensitivity ranging from 50% to 90 % and specificity around 70% to 80% depending on ...

Phase