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Melanoma Clinical Trials

A listing of Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (541) clinical trials

Pembrolizumab in Advanced/Metastatic Acral Lentiginous Melanoma

To determine the Overall Response Rate (ORR), as defined as rate of complete response (CR) and partial response (PR) as per RECIST 1.1 in biological treatment-nave patients with acral lentiginous melanoma treated with pembrolizumab

Phase

Study of the Anti-PD-1 Antibody Nivolumab in Combination With Dabrafenib and/or Trametinib in Patients With BRAF or NRAS-Mutated Metastatic Melanoma

Study Groups: If you are found to be eligible to take part in this study, you will be assigned to 1 of 2 study groups based on the type of mutation you have. If you are in Group A, you will receive nivolumab, dabrafenib, and trametinib (BRAF-mutated patients). If you ...

Phase

Retrospective Analysis of Response Markers and Adverse Events in Melanoma Patients Treated With Pembrolizumab

This study is a retrospective cohort study. A database will be created from the data available of all patients that have participate in the named patient program for pembrolizumab in the Netherlands. This database will be used for analysis of response markers and for an evaluation of adverse events.

Phase N/A

Nivo/Ipi Combination Therapy in Symptomatic Brain Metastases

This study is an open label, single arm, phase II clinical trial of prospectively collected data evaluating efficacy and safety of nivolumab in metastatic melanoma patients with symptomatic brain metastases. It will be conducted in several study centers in the Netherlands. Patients with radiologic evidence of brain metastases and who ...

Phase

Clinical Study of CMP-001 in Combination With Pembrolizumab or as a Monotherapy

Objectives Primary (Part 1): To determine the recommended Phase 2 dose of CMP-001 when given in combination with pembrolizumab in subjects with advanced melanoma. Primary (Part 2): To assess and describe the safety profile of CMP-001 when administered as monotherapy Methodology This is a multicenter, open-label, Phase 1b clinical study ...

Phase

Identification of Predictive Parameters for Colitis in Melanoma Patients Treated With Immunotherapy.

Immunotherapy with immune checkpoint-inhibitors is standard treatment for patients with melanoma. However, in about 15% of patients treated with Ipilimumab a grade 3-4 colitis will occur. In programmed cell death protein 1 (PD1) inhibitors colitis is also seen as adverse event, although less prominent. We want to find a good ...

Phase N/A

CD40 Agonistic Antibody APX005M in Combination With Nivolumab

APX005M-002 is an open-label Phase 1-2 study and comprises a dose-escalation portion (Phase followed by a Phase 2 tumor specific portion. Eligible subjects with non-small cell lung cancer or metastatic melanoma will receive intravenous APX005M in combination with nivolumab until disease progression, unacceptable toxicity or death, whichever occurs first. Study ...

Phase

Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery

This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope ...

Phase

Diagnosing Melanoma Squamous Cell Carcinoma and Basal Cell Carcinoma Using the Spectra-Scope

The Speclipse Spectra-Scope consists of the light collection module and the spectral analysis module. The light collection module is attached to the handpiece of short pulse (a few nanoseconds) Nd:YAG (neodymium-doped yttrium aluminium garnet) commercial cosmetic laser, and the analysis module is placed on the laser. When Nd:YAG laser is ...

Phase N/A

Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss

Study Groups: If you are found to be eligible to take part in this study, you will be assigned to a study group based on when you join this study. Up to 3 groups of 3-6 participants will be enrolled in Phase 1 of the study, and up to 35 ...

Phase