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Melanoma Clinical Trials

A listing of Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (103) clinical trials

In Vivo Real-time Detection of Circulating Melanoma Cells

Study Population: Approximately 80 subjects will be consented in order to achieve an enrollment goal of 75 subjects at this institution in three cohorts as follows: Cohort #1 will consist of fifteen healthy control subjects, ten of whom will be Caucasian and five of whom will be African-American. Subjects in ...

Phase N/A

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination of selected patients with XP, XP/CS, CS, or TTD and follow their clinical course. We ...

Phase N/A

Evaluation for NCI Surgery Branch Clinical Studies

Background Potential research candidates undergo thorough screening including laboratory tests, scans, x-rays and review of pathology slides to determine initial eligibility for Surgery Branch research protocols. Objectives To permit evaluation of patients referred to the NCI Surgery Branch in order to identify individuals who will be suitable candidates for Surgery ...

Phase N/A

Genetic and Clinical Study of Patients With Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

OBJECTIVES: - Identify patients or confirm suspected cases of xeroderma pigmentosum (XP), Cockayne syndrome (CS), XP/CS, or trichothiodystrophy (TTD). - Document presence or absence of cancers (skin, eye, tongue, or internal) in these patients. - Document atypical features or unusual environmental exposures of these patients. - Examine tissue (skin, blood, ...

Phase N/A

Screening Patients for NCI Protocol Eligibility

Background Patients and healthy volenteerswho are being evaluated for NIH Intramural Research Program (IRP) protocols must be screened to determine whether they meet the eligibility criteria prior to enrollment. Performing invasive procedures for the sole purpose of obtaining tissue specimens or biological fluids for research purposes is often not ethically ...

Phase N/A

Clinical Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma

Background Persons may be prone to develop melanoma for a variety of reasons including: family history; environmental exposures; other malignant or premalignant conditions which may or may not be heritable; immune deficiency; or, preneoplastic conditions such as dysplastic nevi. Investigations of individuals and families at high risk of melanoma have ...

Phase N/A

Study of Individuals and Families at High Risk for Melanoma

OBJECTIVES: - Evaluate and define the clinical spectrum and natural history of disease in syndromes predisposing individuals and families to melanoma. - Evaluate potential precursor states of disease in families at risk for melanoma. - Quantify risks of melanoma, pancreatic cancer, and other cancers in family members. - Map, clone, ...

Phase N/A

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum

Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozygote individuals has not been fully studied. We plan to study ...

Phase N/A

Immune Responses in Prostate Lung Melanoma and Breast Cancer Patients Following Stereotactic Body Radiotherapy (SBRT) Intensity Modulated Radiotherapy (IMRT) or Brachytherapy

Success of cancer immunotherapy is limited by the ability of solid tumors to evade local and systemic antitumoral immune responses. Several mechanisms of tumor immune evasion have been identified, including low intratumor expression of antigens and elevated expression of inhibitory co-regulatory molecules. An effective immunotherapy is one which would induce ...

Phase N/A

Collecting Tissue Samples From Patients With Melanocytic Nevi or Pigmented Lesions

OBJECTIVES: Primary - Obtain tissue from benign melanocytic nevi and LCMN for experimental study. - Refine culture and immortalization methods for melanocytes derived from melanocytic nevi that permits in vitro expansion of these cells for functional study. - Correlate clinical and dermoscopic observations of primary melanoma with histopathology to establish ...

Phase N/A