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Chronic Myeloid Leukemia Clinical Trials

A listing of Chronic Myeloid Leukemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (22) clinical trials

Analyses of Human Samples Collected in Clinical Trials

Various human samples (e.g., serum, plasma, whole blood, erythrocytes, urine, feces, bile, and/or saliva) will be collected from cancer patients enrolled on approved clinical trials, in accordance with the local protocol. These trials are being conducted at outside institutions, in collaboration with the National Cancer Institute (NCI) and the samples ...

Phase N/A

Registration of Children With CML and Treatment With Imatinib

Indication: Newly diagnosed pediatric patients with bcr-abl-positive CML. Design: Multicenter, non-randomized, open, prospective clinical trial. Objectives: Primary: - assessment of antileukemic activity of imatinib in children and adolescents with Philadelphia chromosome-positive chronic myeloid leukemia Secondary: - assessment of the time-to event-efficacy variables - correlation of the quality of haematological, cytogenetical ...

Phase N/A

Early Diagnosis of Aspergillosis in Patients at High Risk of Fungal Infection Caused by Treatment for Hematologic Cancer or Other Disease

OBJECTIVES: Primary - Determine the test characteristics of galactomannan (GM) ELISA using serum and bronchoalveolar lavage fluid (BALF) collected from patients at high risk of invasive fungal infection. - Determine the test characteristics of aspergillus PCR using blood and BALF samples collected from these patients. - Evaluate the role of ...

Phase N/A

Study of Radiation Exposure in Chernobyl Clean-up Workers With Leukemia Multiple Myeloma or Myelodysplasia

OBJECTIVES: Primary - To test the hypothesis that there is a dose-related increase in risk of leukemia in the liquidators involved in the cleanup work after the Chernobyl Nuclear Power Plant accident in northern Ukraine in 1986. - To test the hypothesis that the magnitude of any observed risk per ...

Phase N/A

T-cell Recovery in Patients With Leukemia Advanced Lymphoma Myelodysplastic Syndrome or Myeloproliferative Disorder Receiving Alemtuzumab and Undergoing Donor Stem Cell Transplant

OBJECTIVES: Primary - To define the biologic recovery and behavior of T-regulatory cells in patients undergoing stem cell transplantation. - To determine if the administration of alemtuzumab as part of conditioning therapy to patients undergoing stem cell transplantation from mismatched-related donors or from matched-unrelated donors permits T-regulatory cell recovery. OUTLINE: ...

Phase N/A

Study for Epidemiology and Characterization of Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leucemia (JMML) in Childhood

The aim of the study is to improve the accuracy of diagnosis for children and adolescents with MDS by a standardized review of morphology and standardized cytogenetic and molecular analysis. The primary objectives of the study are: - To evaluate the frequency of the different subtypes of MDS in childhood ...

Phase N/A

Magnetic Acupressure in Reducing Pain in Cancer Patients Undergoing Bone Marrow Aspiration and Biopsy

OBJECTIVES: Primary - To compare pain rating in cancer patients undergoing bone marrow aspiration and biopsy (BMAB) treated with magnetic acupressure at bilateral large intestine 4 (LI 4) points vs sham acupressure at bilateral proximal fourth interosseus space of the hand. Secondary - To compare the duration of BMAB, patient's ...

Phase N/A

Chart Review Study of Chronic Myelogenous Leukemia (CML) Patients Treated With Imatinib Outside of a Clinical Trial

PATIENT POPULATION: All patients with CML in any phase of the disease (chronic, accelerated or blast phase) that has received treatment with imatinib not on an MDACC clinical trial regardless of prior treatment history, and has had at least one clinic visit at MDACC will be eligible. STUDY PLAN: The ...

Phase N/A

Stem Cell Transplant for Hematological Malignancy

Preparative regimen using total body irradiation (TBI) and cyclophosphamide: 1. on day -6 and -5: cyclophosphamide is given, 2. on day -4, -3, -2, and -1: TBI is given, 3. on day 0: stem cell or bone marrow is infused. Alternate preparative therapy for patients not able to receive TBI ...

Phase N/A

Fludarabine Cyclophosphamide and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing a Donor Umbilical Cord Blood Transplant for Hematologic Cancer

OBJECTIVES: - Determine the frequency, extent, and rate of donor (myeloid and lymphoid) engraftment in patients with serious hematologic malignancies treated with nonmyeloablative conditioning regimen comprising fludarabine, cyclophosphamide, and low-dose total-body irradiation followed by unrelated allogeneic umbilical cord blood transplantation and post-transplant immunosuppression comprising cyclosporine and mycophenolate mofetil. - Correlate ...

Phase N/A