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Heart Transplantation Clinical Trials

A listing of Heart Transplantation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (13) clinical trials

Heart TIMING - Heart Transplantation IMagING

12-lead ECG - Resting standard 12-lead digital ECG will be recorded. Extended analysis will be performed according to the latest recommendations. Holter ECG - 24 hour Holter ECG will be recorded. Extended Holter ECG analysis will be performed. Life quality questionnaire, patient history - Detailed questionnaire about personal and family ...

Phase N/A

Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation

The current standard for biopsy-based diagnoses of rejection of heart transplants is the ISHLT classification from 2004, which represents a widely-used international consensus, based on morphological criteria of the cellular infiltrate within the myocardial specimen system with certainties and some arbitrary and blurred parameters. Recent data-driven approaches using molecular and ...

Phase N/A

Study of Heart Transplant Rejection

Cardiac transplantation has been successful in improving survival in end stage heart failure. But graft rejection has limited survival after transplantation. In the first year, acute cellular rejection and infection remain the most common causes of morbidity and mortality. Afterwards, cardiac allograft vasculopathy (CAV), as a result of chronic vascular ...

Phase N/A

Bioelectrical Impedance Spectroscopy in Heart Transplantation: Tracking Post-Transplant Changes in Body Composition and Correlation With Conventional Preoperative Risk Assessment Modalities

This is a prospective cohort study, with study visits at Enrollment and subsequently at 10 days , 1 month (+/- 7 days), 3 months (+/- 7 days) , 6 months (+/- 14 days) , and 12 months (+/- 14 days) after heart transplant surgery. BIS measurements will be performed on ...

Phase N/A

Non Invasive Detection of Cardiac Allograft Rejection by Circulating microRNAs

Heart transplantation is the only available long-term treatment option for patients with terminal heart failure. Despite considerable progress in immunosuppressive regimens, allograft rejection remains a major cause of graft loss. Majority of cardiac allograft rejection are asymptomatic. Only severe rejection goes along with cardiac dysfunction. This clinical latency makes the ...

Phase N/A

Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children

EBV-associated post-transplant lymphoproliferative disease (PTLD) is the most common malignancy in children after transplant. Diagnosis and effective treatment of the EBV-associated cancer is hampered by our inability to determine which children are at risk of developing these cancers and to detect the cancer at an early stage. In this study, ...

Phase N/A

Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates

Transplantation is the therapy of choice for most patients with stage 5 chronic kidney disease (CKD) and end stage renal disease (ESRD). Kidney transplantation improves quality of life and overall survival rates. Cardiovascular disease is the most common complication and leading cause of death in the transplant population. In order ...

Phase N/A

Prevalence and Dynamic of Sleep-disordered Breathing in Patients Pre and Post Heart Transplantation

Sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. This study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation, as ...

Phase N/A

Advanced Cardiac Imaging in Cardiac Allograft Vasculopathy

Heart transplantation is a viable treatment option for select patients with end-stage heart failure, with 1-year survival rates for heart transplantation approximating 85%. Of those who survive the first year, >90% are alive at 5 years. In the early post-transplant period, rejection of the donor heart due to activation of ...

Phase N/A

Impact of Donor and Recipient ST2 / IL-33 Pathway After Heart Transplantation

Soluble protein sST2 has recently become a prognostic biomarker in the context of acute myocardial infarction and chronic heart failure, and recent studies also show that sST2 is involved in acute rejection of the cardiac graft in recipients. Experimental studies confirm that the ST2 / IL-33 pathway is involved in ...

Phase N/A