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Metastatic Melanoma Clinical Trials

A listing of Metastatic Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (83) clinical trials

This randomized phase II trial studies how well molecularly targeted therapy works in treating patients with melanoma that has spread to other parts of the body. Patients must have received or do not qualify for prior immunotherapy. Targeted therapy is a type of treatment that uses drugs or other substances ...

Phase

The purpose of the study is to assess the efficacy, safety, and tolerability when combining pembrolizumab with epacadostat or placebo in subjects with unresectable or metastatic melanoma.

Phase

Combination of Temozolomide and Sunitinib in Treatment of Patients With Metastatic and Unresectable Malignant Melanoma

The therapy with a combination of a chemotherapeutic agent with a known activity against melanoma (temozolomide) and a new small molecule that inhibits angiogenesis (sunitinib malate) will be tested in this clinical trial. Both agents have been approved for use in humans with different types of malignancies, and the tolerated ...

Phase

Effects of Monoclonal Antibody GC1008 in Blood Samples From Patients With Unresectable Locally Advanced or Metastatic Kidney Cancer or Malignant Melanoma Treated on Clinical Trial NCI-06-C-0200

OBJECTIVES: - To determine whether treatment with human anti-TGF-beta monoclonal antibody GC1008 results in a detectable decrease in phospho-Smad2 levels in freshly collected blood samples from patients with unresectable locally advanced or metastatic renal cell carcinoma or malignant melanoma treated on clinical trial NCI-06-C-0200. - To determine whether the decrease ...

Phase N/A

Study of Gene Modified Immune Cells in Patients With Advanced Melanoma

This is a two-stage phase II clinical trial with the combined primary endpoints to determine the safety, feasibility and anti-tumor activity of adoptive transfer of peripheral blood mononuclear cells (PBMC) genetically engineered to express the alpha and beta chains of a high affinity T cell receptor (TCR) specific for the ...

Phase

Treatment of a Resistant Disease Using Decitabine Combined With Vemurafenib Plus Cobimetinib

Primary Objectives Evaluate the safety and tolerability of the proposed schedule of decitabine and Vemurafenib plus Cobimetinib in the treatment of metastatic melanoma. Assess tumor response rates by RECIST criteria Secondary Objectives To measure the time to progression of patients treated with this combination in comparison to patients treated historically ...

Phase

Circulating Melanoma Cells in Metastatic Patients Treated With Selective BRAF Inhibitors

This is an observational prospective pilot study aimed to investigate the association between changes of total and apoptotic CMC count and disease progression in MM patients undergoing treatment with selective inhibitors of mutated B-RAF.

Phase N/A

A Phase 1b Safety Study of CMB305 (Sequentially Administered LV305 and G305) in Patients With Locally Advanced Relapsed or Metastatic Cancer Expressing NY-ESO-1

This study is designed to investigate and examine the safety and immunogenicity of the combinatorial regimen called CMB305, where intradermal LV305 is administered sequentially with intramuscular G305 over three months. During Part 1, a dose escalation design will be utilized in patients with melanoma, NSCLC, ovarian cancer, or sarcoma. After ...

Phase

PV-10 in Combination With Pembrolizumab for Treatment of Metastatic Melanoma

Up to 24 eligible subjects will be enrolled in the Phase 1b portion of the study. Each subject in this cohort will receive the combination of IL PV-10 and pembrolizumab. A total of an estimated 120 eligible subjects will be randomized in a 1:1 ratio to the two treatment arms ...

Phase

Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma

Leptomeningeal Disease: (Cohort D): Study Visits: You are expected to stay in the Houston area for at least 21 days in order to take part in this study. During this study, you will have the following tests and procedures: - You will have an MRI of the complete spine and ...

Phase