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Chronic Obstructive Lung Disease Clinical Trials

A listing of Chronic Obstructive Lung Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (307) clinical trials

We are looking for individuals to participate in a research study to determine the safety and efficacy of an investigational medication. Eligibility Criteria: If you are: - 40 years of age or older - are a previous or current smoker - have a diagnosis of chronic obstructive pulmonary disease (COPD) ...

Phase N/A

This study will be testing an investigational medication for COPD Eligibility Criteria: -Age 40 years or older -Diagnosis of COPD for at least 12 months -Current Smoker or Ex-Smoker -Other criteria may apply Other Details: Qualified volunteers will receive study medication, study supplies and any study required testing at no ...

Phase

Seasonal Influenza Vaccine Quadrivalent Versus Trivalent in Patients With Advanced Chronic Obstructive Pulmonary Disease

Primary Objectives: To evaluate the magnitude of the humoral immune responses to quadrivalent vs trivalent influenza vaccines in adults between the age of 50 and 64 years with a prior diagnosis of GOLD Stage C and D COPD (vs. those patients without COPD). To demonstrate immunogenicity by measuring hemagglutination inhibiting ...

Phase

A Randomized Multicenter Open-label Parallel-group 12-week Study to Assess the Efficacy and Safety of Switching From Tiotropium to QVA149 (Indacaterol Maleate/Glycopyrronium Bromide) in Symptomatic Mild to Moderate COPD Patients

To demonstrate superiority of QVA149 (110/50 g) once daily compared to tiotropium 18 g once daily in terms of trough forced expiratory volume in 1 second (FEV1) (mean of 45 min and 15 min pre-dose) following 12 weeks of treatment in mild to moderate symptomatic COPD patients

Phase

Ultibro Versus Spiriva Alone to Reduce Exertional Dyspnea in Patients With Moderate to Severe COPD

The foundation of COPD therapy is to combine inhaled therapy to optimize benefits as it was done several years ago by associating short-acting 2-agonists and muscarinic antagonist. The recent availability of once-daily LABA/LAMA fixed combination products makes this therapeutic strategy even more appealing and appears as a promising treatment option ...

Phase

Evaluation of a Multi-professional Breathlessness Service for Patients With Breathlessness Due to Any Advanced Disease

Breathlessness is a common and distressing symptom in patients with advanced diseases like cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF) or lung fibrosis, which broadly impacts on patients' quality of life and may result in high burden for carers. This single-blinded randomized controlled fast track trial evaluates ...

Phase N/A

QVA Mechanistic Efficacy Study (Receptor Effects Etc)

Current physiological measures of small airway dysfunction are limited, subject to a high degree of variability and do not allow a quantitative assessment of global and regional ventilation defects. The MRI approach represents an opportunity to better understand the impact of a potent dual bronchodilator on the small and central ...

Phase

A Study to Assess the Effect of CK-2127107 on Physical Function in Subjects With Chronic Obstructive Pulmonary Disease

Enrolled participants will be randomly assigned to 1 of 2 treatment sequences and will receive both CK-2127107 and matching placebo over 2 treatment periods.

Phase

Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial

Inhaled corticosteroids (ICS) are commonly prescribed for patients with chronic obstructive pulmonary disease (COPD), but their role in the management of COPD is currently being re-evaluated in light of new evidence and the emergence of alternative treatments. Studies have shown that the use of ICS and particularly ICS combined with ...

Phase

Pharmacodynamics Pharmacokinetics and Safety of Two Doses of CHF6001 DPI in Subjects With Moderate Severe COPD

The purpose of this study is to obtain information on the effects of two doses of CHF6001 on sputum and blood biomarkers of inflammation in subjects with symptomatic COPD with moderate, severe airflow limitation and with chronic bronchitis. The efficacy of the treatment will also be measured using forced oscillometry ...

Phase