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Chronic Obstructive Lung Disease Clinical Trials

A listing of Chronic Obstructive Lung Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (375) clinical trials

This is a research study for chronic obstructive pulmonary disease (COPD). Subjects who meet inclusion criteria will be assigned to one of three doses of tiotropium. Two of these doses will be delivered via a novel inhalation device. The third dose will be delivered by the HandiHaler. This study is ...

Phase N/A

A RESEARCH STUDY IS CURRENTLY BEING CONDUCTED IN YOUR AREA TO INVESTIGATE AN EXPERIMENTAL ANTI-COPD MEDICATION TO EVALUATE ITS EFFECT IN REDUCING WORSENING OF YOUR COPD.

Phase N/A

Integrative-omics of the Disordered COPD Small Airway Epithelium

Hypothesis: We hypothesize that the disordered differentiation of the SAE that characterizes COPD results from the complex interaction of cigarette smoke components with a hierarchy of genetic, epigenetic, gene expression and metabolomics network interactions as the BC differentiate into a mucociliary epithelium. Specific aim 1. Using an integrated network systems ...

Phase N/A

Influence of Mechanical Ventilation Modes on the Efficacy of Nebulized Bronchodilator

2. OBJECTIVES 2.1 Primary To evaluate the influence of mechanical ventilation modes in the efficacy of nebulized bronchodilator in ventilator dependent patients with obstructive pulmonary disease. 2.2 Secondary To compare regional ventilation distribution through Ventilation Surface Area (VSA) and Tidal Impedance Variation (TIV or Z) by electrical impedance tomography (EIT) ...

Phase N/A

Evaluation of Novel Lung Function Parameters and Quantitative Computed Tomography (qCT) in Patients With Pulmonary Disease

Current diagnostic tools used in pulmonary disease often do not meet the challenges set by the respective pathophysiology. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various pulmonary diseases.

Phase N/A

HIV-related Accelerated Aging of the Airway Epithelium

While the epidemiologic data linking HIV infection to an increased risk for COPD is clear, the pathogenesis of the accelerated development of COPD in HIV infected smokers is not understood. We have focused on the SAE as the central target for the accelerated development of COPD in HIV infected smokers, ...

Phase N/A

Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of COPD.

Phase N/A

Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD

Changes within the small airways of the lungs represent the key element in the mechanism of COPD, as they precede the development of emphysema and contribute to the progressive decline in expiratory airflow. One of the key features of COPD is the remodeling of the small airway epithelium (SAE), and ...

Phase N/A

Right Heart Dysfunction and Pulmonary Hypertension Evaluation in Airway Disease Using Cardiac Magnetic Resonance

Background and Importance: Chronic respiratory diseases, which include asthma, COPD and pulmonary hypertension (PH), were responsible for 4.2 million deaths globally in 2008. COPD and asthma affect more than 500 million people worldwide and present an enormous health and economic burden. Exacerbations of airway disease contribute to disease progression and ...

Phase N/A

HFNC Effect on BCSS in Patients With COPD

This is a prospective pilot study. Targeted population include patients with COPD, non-oxygen dependent, with a baseline normal bicarbonate on previous lab (within 6 months of enrollment). Patients will be randomly selected to be part of the study sample. Recruitment will occur in both inpatient and outpatient settings. An email ...

Phase N/A