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Gastroesophageal Reflux Disease (GERD) Clinical Trials

A listing of Gastroesophageal Reflux Disease (GERD) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (40) clinical trials

Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children

Nissen fundoplication is a commonly performed procedure in infants and children with gastroesophageal reflux and a variety of other medical conditions including respiratory compromise, severe neurologic impairment, failure to thrive and swallowing dysfunction. Randomized controlled trials in adults have shown that laparoscopic fundoplication is a safe procedure that results in ...

Phase N/A

A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treating Gastroesophageal Reflux Disease Among Chinese Patients

The incidence of gastroesophageal reflux disease (GERD) is rising among Asian population. A recent systematic review showed among Chinese population, the prevalence of GERD can be up to 5% (2). Currently, the standard treatment for GERD is acid suppression using proton pump inhibitors (PPI) which can achieve a symptomatic relief ...

Phase

Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection

The purpose of this study is to evaluate response to non-erosive reflux disease (NERD) treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings. The researchers will compare two different drug regimens for the NERD subjects to evaluate their effectiveness in reducing NERD-related symptoms. In addition, ...

Phase N/A

STRETTA Radio Frequency Ablation (RFA) v/s Sham Therapy for the Treatment of Refractory GERD

Gastro-esophageal reflux disease (GERD) is a chronic disorder with significant impact on the quality of life of patients. It may also lead to several complications like peptic strictures, ulcerations, Barrett 's disease and subsequently adenocarcinoma of the esophagus. Proton pump inhibitors (PPIs) are the mainstay of GERD treatment, with up ...

Phase

Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is a chronic disease characterized by symptoms of heartburn and acid regurgitation. Uncontrolled GERD can significantly impact quality of life. The use of proton pump inhibitors (PPI) remains the mainstay therapy. However, the efficacy of this intervention is often hampered by adherence, costs, and the risks ...

Phase N/A

Determining Risk Factors for Successful PPI Weaning

Gastroesophageal Reflux Disease ("GERD") can happen when stomach acid flows backward into your esophagus (tube from the mouth to the stomach), causing symptoms such as heartburn. Proton pump inhibitors (called "PPIs") are a type of medication that reduce acid in the stomach and are used to reduce the discomfort from ...

Phase N/A

Implementation of PPI Medication PGX Testing

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO IMPLEMENT PHARMACOGENOMIC (PGX) TESTING OF APPROVED GENE-DRUG PAIRS TO MAXIMIZE THE EFFICACY AND MINIMIZE ADVERSE EVENTS FOR DRUGS THAT ARE USED TO TREAT CHILDHOOD DISEASE. PERSONALIZED MEDICINE, THAT IS, THE USE OF THE PATIENT'S OWN GENETIC INFORMATION TO PREDICT THE RIGHT DOSE ...

Phase

Cromolyn Detection of Silent Aspiration

The overall purpose of this project is to develop and validate a simple, non-invasive method to detect aspiration of gastro-intestinal fluid into the respiratory tract. In the inpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 4 ingestions (at 2h intervals) of a ...

Phase

Efficacy and Safety Evaluation of Neobianacid in GERD and EPS

Comparison of heartburn or epigastric pain severity following administration of Neobianacid (Group B) or omeprazole (Group A) from day 0 to day 27. An ad-hoc placebo will be also administered in both treatment arms. Then, a following phase (day 28-55) will follows in which Neobianacid will be administered (on demand) ...

Phase

Novel Endoluminal Clinical TreAtment of Reflux

This is a prospective, multi-center, double-blind randomized controlled trial designed to demonstrate the safety and efficacy of Aluvra for the treatment of GERD.

Phase N/A