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Affective Disorders Clinical Trials

A listing of Affective Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (334) clinical trials

Can Imagination Change Upsetting Memories of Trauma?

Research suggests that imagination is a powerful tool to change images inside our heads (e.g. memories) and make them less upsetting. It is thought that this occurs through changing the meaning attached to the memory (e.g. I am weak), therefore making it less upsetting to remember. Research has also linked ...


A Study of Pregnant and Postpartum Women With and Without Mood Disorders

Postpartum Depression (PPD) is a serious syndrome which resembles a major depressive episode and occurs in 10-20% of all mothers in the year following delivery. In addition, 20 - 30 % of women with Bipolar Disorder will experience postpartum psychosis (mania) and at least 20 % will experience a postpartum ...

Phase N/A

Vortioxetine add-on Treatment Improves the Symptoms in Patients With Bipolar Depression

In this study, the investigators are going to examine the efficacy of vortioxetine augmentation in bipolar disorder patients with depressive symptoms. The study design is a double-blinded 6-week prospective study. It would be useful for clinicians because it will provide new evidence for the effect of vortioxetine in bipolar disorder ...


Can Cognitive Training Decrease Reactive Aggression?

Neurocognitive and social cognitive impairments are contributors to negative emotionality and impulsive aggression in people with schizophrenia. Impulsive aggression poses several challenges to the care of people with schizophrenia. These include a greater risk of rehospitalization and longer hospital stays, involvement with the criminal justice system, and increased risk of ...

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Imaging 5HT7 Antagonist Effects in Bipolar Disorder

OBJECTIVE Primary To determine the effect of 5HT7 antagonism on cognition related brain activations and cognitive performance in people with bipolar disorder. Secondary To examine the effect of 5HT7 antagonism on emotional processing related brain activations in people with bipolar disorder. To examine the effect of 5HT7 antagonism on behavioral ...

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Mindfulness Psychoeducation Program for Schizophrenia

There is increasing evidence to demonstrate the safety and effectiveness of mindfulness-based psychoeducation programme (MBPP) for Chinese people with schizophrenia. A single-blind, multi-site, pragmatic randomised controlled trial conducted in Hong Kong, mainland China, and Taiwan with 300 participants consistently demonstrated significant improvement in regard to insight of illness, functioning, mental ...

Phase N/A

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

In this study, the investigators will examine changes in brain activity from Low Field Magnetic Stimulation in subjects over the age of 50 with bipolar disorder who are currently depressed using functional Magnetic Resonance Imaging and proton Magnetic Resonance Spectroscopy. Following screening visits, study procedures include two visits, at least ...

Phase N/A


The chronic effect of the active product on mood, anxiety, perceived stress, quality of life and cortisol secretion & metabolism will be assessed through validated questionnaires and urine collection after 2, 4 and 8 weeks of daily supplementation. The acute effect of the product will be assessed after a single ...

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Music Therapy for Persons With Dementia

Following the consent process, the PI will collect demographics, music background, and preference information from participants' family and/or facility care staff. Where possible, the PI will ask participants directly about their music preferences. The main study period will last 9 weeks and will consist of the following: (a) a "pre-study" ...

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Assessment of Efficacy of a Psychological Therapy in Inpatients With a Schizophrenic Psychosis

Psychotic disorders, and particularly schizophrenia, are severe psychiatric disorders, characterized by psychotic symptoms (mainly hallucinations and delusions), disorganized speech, thought and behavior, and negative symptoms like blunted affect. People who have schizophrenia are chronically impaired. Schizophrenia is one of the first causes of disability worldwide with enormous direct and indirect ...

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