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Liver Transplantation Clinical Trials

A listing of Liver Transplantation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (147) clinical trials

SVC and Its Relationship to CVP Measurements in Liver Transplantation

Central venous pressure (CVP) measured invasively through a central venous catheter in the internal jugular vein or through a right atrial port of a pulmonary artery catheter is commonly used during liver transplant surgery. CVP measurements at the SVC-RA junction are a function of circulating blood volume, right ventricle function, ...

Phase N/A

MSC Therapy in Liver Transplantation

The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from diagnostic samples of bone marrow aspirates (2-5 mL) or using ...


Albumin Mass Balance in Liver Transplantation

Background Capillary leakage has been recognized to be associated with surgery and inflammation [Fleck 1985]. In liver transplantation considerable amounts of exogenous albumin is administered to support circulatory stability and a post operative plasma albumin concentration of 25 g/L to facilitate interpretation of immuno suppressive drug concentrations. However, the long ...

Phase N/A

co2 Gap and co2/o2 Ratio in Liver Transplant Patients

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at ...

Phase N/A

Validation of Cardiometry in Resuscitation of Patients Undergoing Liver Transplantation

Induction of anaesthesia will be by using propofol ( IV, fentanyl (1-2g. kg) IV and atracurium (0.5 IV. Anaesthesia will be maintained with Sevoflurane adjusted between 1-2% in an air oxygen mix (FiO2 0.6), fentanyl infusion at 1-2 and atracurium infusion at 0.5 h. Mechanical ventilation will ...

Phase N/A

Liver Immunosuppression Free Trial

This is a prospective, multi-centre, phase IV, biomarker-strategy design trial with a randomised control group in which adult liver transplant recipients will undergo immunosuppression (IS) withdrawal. Immunosuppression drugs (IS) are: Tacrolimus, cyclosporine and/or mycophenolic acid, mycophenolate mofetil or azathioprine. Enrolled participants will be randomised 1:1 to either: 1) Non-Biomarker-based IS ...


Low-dose IL-2 for Treg Expansion and Tolerance (LITE)

Transplantation remains the most successful treatment for end-stage organ failure, but the need to administer life-long immunosuppression (IS) to prevent rejection limits patient survival. Liver transplantation is the only transplantation setting in which a sizeable proportion of patients spontaneously develop "operational tolerance", a phenomenon defined by the maintenance of stable ...


Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Approximately half of all patients develop metastases, often to the liver or lung. Surgical treatment of liver metastases (LM) is the only curative treatment option; however, it has been estimated that only 20-40% of patients are candidates for liver ...

Phase N/A

Removable Intraductal Stenting in Duct-to-duct Biliary Reconstruction in Liver Transplantation

Comparative, multicentric, prospective, randomized non-blinded, two-groups study. The follow-up is set at six months postoperative for a good screening of the majority of biliary complications. The inclusion period is set at 3.5 years, for total study duration of 4 years. The patients' inclusion will be made in 7 liver transplantation ...

Phase N/A

Thromboelastometry in Liver Transplantation

Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation. In a post-hoc analysis from a randomized study recently conducted by our group, presurgical values of MA10 Extem < 35 mm are highly predictive of RBC administration , with no further improvement over MA10 Extem >40 ...

Phase N/A