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Liver Transplantation Clinical Trials

A listing of Liver Transplantation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (135) clinical trials

SVC and Its Relationship to CVP Measurements in Liver Transplantation

Central venous pressure (CVP) measured invasively through a central venous catheter in the internal jugular vein or through a right atrial port of a pulmonary artery catheter is commonly used during liver transplant surgery. CVP measurements at the SVC-RA junction are a function of circulating blood volume, right ventricle function, ...

Phase N/A

MSC Therapy in Liver Transplantation

The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from diagnostic samples of bone marrow aspirates (2-5 mL) or using ...


Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated Irresectable Colorectal Liver Metastases

Purpose The purpose of the present study is to evaluate a two-stage hepatectomy with a left-lateral living donor liver transplantation and right portal vein ligation for treatment of otherwise irresectable liver metastases of colorectal carcinoma in curative intent. Study setting The study is an investigator-initiated, bi-institutional, one-arm trial. For ethical ...

Phase N/A

Albumin Mass Balance in Liver Transplantation

Background Capillary leakage has been recognized to be associated with surgery and inflammation [Fleck 1985]. In liver transplantation considerable amounts of exogenous albumin is administered to support circulatory stability and a post operative plasma albumin concentration of 25 g/L to facilitate interpretation of immuno suppressive drug concentrations. However, the long ...

Phase N/A

Trial of Faecal Microbiota Transplantation in Cirrhosis

Humans are colonized by a diverse range of microbes, the most abundantly inhabited being the gastrointestinal tract which anatomically commences at the oral mucosa, with the colonic lumen being the most densely populated. The gut microbiota consist mainly of bacteria, but it is worth remembering that fungi, viruses, archaea and ...


co2 Gap and co2/o2 Ratio in Liver Transplant Patients

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at ...

Phase N/A

Validation of Cardiometry in Resuscitation of Patients Undergoing Liver Transplantation

Induction of anaesthesia will be by using propofol ( IV, fentanyl (1-2g. kg) IV and atracurium (0.5 IV. Anaesthesia will be maintained with Sevoflurane adjusted between 1-2% in an air oxygen mix (FiO2 0.6), fentanyl infusion at 1-2 and atracurium infusion at 0.5 h. Mechanical ventilation will ...

Phase N/A

WP01 - Normothermic Liver Preservation

A multicenter randomized controlled trial to compare the efficacy of ex-vivo normothermic machine profusion with static cold storage in human liver transplantation.


Liver Immunosuppression Free Trial

This is a prospective, multi-centre, phase IV, biomarker-strategy design trial with a randomised control group in which adult liver transplant recipients will undergo immunosuppression (IS) withdrawal. Immunosuppression drugs (IS) are: Tacrolimus, cyclosporine and/or mycophenolic acid, mycophenolate mofetil or azathioprine. Enrolled participants will be randomised 1:1 to either: 1) Non-Biomarker-based IS ...


Low-dose IL-2 for Treg Expansion and Tolerance (LITE)

Transplantation remains the most successful treatment for end-stage organ failure, but the need to administer life-long immunosuppression (IS) to prevent rejection limits patient survival. Liver transplantation is the only transplantation setting in which a sizeable proportion of patients spontaneously develop "operational tolerance", a phenomenon defined by the maintenance of stable ...