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Cushing's Disease Clinical Trials

A listing of Cushing's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (20) clinical trials

Seoul National University Pituitary Disease Cohort Study

Subjects for this study will be recruited if they are: Adults, male or female aged 18 years or older Have been diagnosed with pituitary diseases

Phase N/A

Long Term Safety and Efficacy of Pasireotide s.c. in Patients With Cushing's Disease

This is a non-interventional, multinational, multi-center post-marketing study, to further document the safety and efficacy of pasireotide s.c. administered in routine clinical practice in patients with Cushing's disease. Patients with Cushing's disease and treated with pasireotide s.c. alone and in combination with other therapies will be monitored. For this study, ...

Phase N/A

Cushing's Disease Complications

At inclusion the following will be investigated and recorded : demographic and personal medical history. Familial medical history related to osteoporosis, cardiovascular disorders and thromboembolism. Current medical treatment. Physical examination. Assessment of basal 24hrs urinary cortisol and salivary cortisol. At baseline (i.e. before specific treatment of Cortisol excess): physical examination, ...

Phase N/A

Dynamic Hormone Diagnostics in Endocrine Disease

Microdialysis fluid will be collected from all participants using the ULTRADIAN dynamic diagnostics system. This is a 3-component collection system which can easily be attached to a belt and allows participants to continue with their normal everyday activities whilst undergoing sampling. The micro-fractions are minute, the volume would normally be ...

Phase N/A

The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)

Cushing Syndrome is a severe condition caused by prolonged exposure to high levels of glucocorticoids. This is a disease with high morbidity and mortality due to metabolic, cardiovascular, coagulative, psychiatric complications of hypercortisolism. The loss of circadian secretion of cortisol is one of the most sensitive and specific diagnostic features ...

Phase N/A

Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

Objective To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma. Methods 234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

Phase N/A

Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome and Bilateral Adrenal Tumors

Adrenal incidentalomas are quite common. About 4 % of the population have adrenal tumors that they are unknown of. Some percentage of this patients produce a little to much cortisol, but not enough to give overt Cushings syndrome. It is shown that slightly elevated cortisol production will give higher blood ...

Phase N/A

Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children.

the investigators have collected saliva samples morning and late evening for cortisol measurements in a total of 330 children ( 660 samples) in the age from 4 to 16 years ols. This samples are going to be used to define a reference range for saliva cortisol in children. The investigators ...

Phase N/A

Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery

This study will investigate the potential for FK506 binding protein 5 (FKBP5) (and other gene expression markers, for example pentraxin 3 [PTX-3], serum/glucocorticoid regulated kinase 1 [SGK1], and glycogen synthase kinase 3 beta [GSK3b]) to be developed as a biomarker for use in diagnosis of Cushing's syndrome, assessment of effectiveness ...

Phase N/A

Quality of Life Fatigue and Cognitive Affective and Emotional Dysfunction in Patients With Cushing's Syndrome

Background Endogenous Cushing's syndrome (CS) is the collective name for several rare disorders of chronic glucocorticoid (GC) excess. The most common causes are ACTH producing pituitary adenoma [Cushing's disease (CD)], cortisol producing adrenal adenoma (CPAA) and ectopic ACTH producing tumors. Cognitive dysfunction, psychiatric disorders, fatigue, and impaired quality of life ...

Phase N/A