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Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (33) clinical trials

Closure of Muscular Ventricular Septal Defects (VSDs) With the AMPLATZER Muscular VSD (MuVSD) Occluder - Post Approval Study

The AMPLATZER Muscular VSD Occluder was approved by the US Food and Drug Administration (FDA) in September, 2007. This study is designed to further evaluate the safety and effectiveness in subjects implanted with the AMPLATZER Muscular VSD Occluder.

Phase N/A

Aortic Regurgitation After Surgical Repair of Outlet-Type Ventricular Septal Defect

Progression of aortic regurgitation (AR) in repaired outlet (juxta-arterial, muscular outlet and perimembranous outlet) ventricular septal defect (VSD) remains unclear. From 1987 to 2002, 411 patients with complete follow-up after repair of outlet VSD constituted the study population. Study end point was aortic valve replacement or mortality. Aortic valve replacement ...

Phase N/A

"Salvage Use" of Recombinant Factor VIIa After Inadequate Haemostasis in Complex Cardiac Surgery

11. 3 Methods Synopsis of Study: A multicentred randomised, double blind, placebo-controlled trial evaluating the efficacy and safety of activated recombinant factor VII (rVIIa) in complex cardiac surgery. Study will be conducted at Austin Hospital, Alfred Hospital and Warringal Private Hospital. The study will have two arms: 1. Those who ...


Role of Left Ventricular Pacing Site

Background. Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. Design. Single-blind, monocentric, randomized cross-over study comparing 11 left ventricular pacing sites in a random order. Intervention. ...

Phase N/A

Calcium Current in Human Heart Cells

Extrapolating pharmacological and surgical therapies from adult (AD) studies to infant (INF) patients is problematic because the knowledge of cellular electrophysiology and molecular biology of human INF heart cells is limited. The investigators have studied developmental differences in rabbit ventricular cells and now extend these studies to atrial and ventricular ...

Phase N/A

Varying Characteristics of Atherogenesis and Cardiopulmonary Bypass Inflammatory Response

BACKGROUND: Over the last decade there has been a tremendous growth in our understanding of genetic influences upon atherogenesis, coagulation, and fibrinolysis. Atherosclerosis plays a major role in the pathophysiology of coronary, cerebral, and peripheral vascular disease. Interventions directed towards the prevention of ASCVD have focused on the use of ...

Phase N/A

Preoperative Dual Antiplatelet Therapy: Platelet Function and Influence of Cardiopulmonary Bypass

Taking antiplatelet medication before cardiac surgery increases the risk for bleeding. The surgical procedure and the use of a heart-lung machine may disturb the function of platelets, why measures to protect the existing function of platelets are of prime concern. The present study aims to compare how two types of ...

Phase N/A

Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDs

This is a prospective, multicenter, single-arm clinical study comparing outcomes with the GORE® CARDIOFORM ASD Occluder to performance goals derived from clinical investigation outcomes for devices indicated for ASD closure.

Phase N/A

COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction

The study is a prospective, non-randomized, multi-center clinical study to assess the safety and effectiveness of pulmonic implantation of the SAPIEN THV in patients with dysfunctional RVOT conduits requiring treatment for moderate or severe pulmonary regurgitation (PR) by transthoracic echocardiography (TTE) and/or RVOT conduit obstruction with a mean gradient of ...

Phase N/A

Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility Study

This is a multi-center prospective, single-arm, non-randomized, open label study to assess feasibility of the Xeltis Bioabsorbable Pulmonary Valved Conduit in subjects requiring Right Ventricular Outflow Tract correction or reconstruction due to congenital heart malformations.

Phase N/A