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Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (111) clinical trials

The Rhytmia System to Determine the Precise Location and Potential Mechanism of Premature Contractions

This is a purely observational study. No special methodology choice, no comparison. The study want to find the determination of precise location of the focus and mechanisms involved constitutes a challenge for conventional electrophysiology, even with tridimensional systems, because of the time needed for accurate delineation of the location (due ...

Phase N/A

Study Evaluating the Safety Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491

The purpose of this Phase 1 study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MYK-491 in patients with DCM and stable heart failure.

Phase

Preserved Umbilical Vein Use as Autologous Shunt Conduits in Neonatal Cardiac Surgery

This is a prospective, single center, safety and feasibility trial to evaluate the use of autologous umbilical vein as shunts or conduits in neonatal cardiac surgery. Subjects will be identified here at the Advanced Fetal Care Center (AFCC) following diagnosis of congenital heart disease (CHD) with single ventricle physiology of ...

Phase N/A

Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle

This is a prospective, single center, safety and feasibility, blinded, randomized trial to evaluate the use of MPCs in children with complex cardiac anatomy requiring surgical repair. Patients scheduled to undergo bidirectional Glenn (BDG) with future plans for LV recruitment, or patients with a history of BDG who are currently ...

Phase

MitraClip and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect Closure

Transcatheter mitral valve repair with the MitraClip system is a therapeutic alternative to surgery in selected high-risk patients. Clip placement requires interatrial transseptal puncture and meticulous manipulation of the steerable sheath. There is evidence that the persistence of a relevant iASD after MitraClip is associated with worse clinical outcomes and ...

Phase N/A

Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Brain Training Program for Children With ASD

Visual puzzles have been used for centuries to facilitate early development in kids. Mental Imagery Therapy for Autism (MITA) is a unique, early-intervention application for children with Autism Spectrum Disorder (ASD). The app includes bright, interactive puzzles designed to help children learn how to mentally integrate multiple features of an ...

Phase N/A

Registry of Cell Therapy in Non-Ischemic Dilated Cardiomyopathy

Registry will include all patients who underwent intracoronary or intramyocardial cell therapy as a part of clinical trials performed at UMC Ljubljana from January 2005 until January 2018. Patients will be followed on regular basis in a dedicated heart failure outpatient clinic, clinical data will be collected and stored in ...

Phase N/A

The Effect on EPCs by Successful Cardiac Occlusion Device Implantation

The objective of this study is to assess the effect, if any, on EPC count and cardiac device implantation. All patients awaiting LAA or PFO/ASD occlusion will firstly be reviewed in a cardiology clinic and assessed. Suitable patients will then be placed on a waiting list for occlusion device implantation ...

Phase N/A

NOACs for Atrial Tachyarrhythmias in Congenital Heart Disease

Rationale: Adult patients with congenital heart disease (CHD) with atrial tachyarrhythmias need to be anticoagulated. It is not known whether non-vitamin K antagonist oral anticoagulants (NOAC) in this patient group are efficient and safe. Aim: The purpose of the NOTE registry is to evaluate the efficacy and safety of NOACs ...

Phase N/A

Cardiac Function After Transcatheter VSD Closure

The investigators will enroll 50 consecutive patients with VSDs from the outpatient clinic of National Taiwan University Children's Hospital and Yi-Da Hospital. All participants will receive transcatheter VSD closure after comprehensive discussion with the clinical physicians and the performing clinicians. However, the investigators do not assign such treatment to the ...

Phase N/A