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Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (158) clinical trials

People with Sickle Cell Anemia are asked to participate in a research study being conducted by Montefiore Medical Center.    Clinicaltrials.gov: NCT03264989

Phase N/A

The purpose of the study is to improve clinical care, and patient knowledge regarding stroke in people with sickle cell disease. Participation will include 1 study visit. This visit will last 2 hours. There will be an MRI scan (1 hour) with IV contrast and one cognitive test that will ...

Phase N/A

For more information please visit: http://clinicaltrials.gov/ct2/show/NCT01794000?term=H7T-MC-TADO&rank=1

Phase N/A

Drug Interaction Study of GBT440 With Caffeine S-warfarin Omeprazole and Midazolam in Healthy Subjects

The purpose of this study to evaluate the effect of concomitant administration of GBT440 on caffeine (a CYP1A2 probe substrate), S warfarin (a CYP2C9 probe substrate), omeprazole (a CYP2C19 probe substrate), and midazolam (a CYP3A4 probe substrate) plasma concentrations.


A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy Subjects

The purpose of this study is to evaluate the relative bioavailability of a single 300 mg dose of GBT440 administered as a high strength (1 × 300 mg) capsule versus a low strength (3 × 100 mg) capsule formulation in healthy fasted subjects.


Therapeutic Anticoagulation Strategy for Acute Chest Syndrome

Acute Chest Syndrome (ACS) is a pulmonary complication of sickle cell disease (SCD) representing the leading cause of death and the second cause of hospitalization among adult patients. Pulmonary vaso-occlusion is one of the main pathophysiologic hypotheses during ACS. Our hypothesis is that therapeutic anticoagulation may reduce the severity of ...


Macitentan in Pulmonary Hypertension of Sickle Cell Disease

Background and Rationale: Sickle cell disease (SCD) affects 250,000 births per year worldwide, with 70-80,000 patients currently residing in the US. Although classically thought of as a genetic hemoglobinopathy, most of the clinical complications are vascular in etiology and pulmonary manifestations are the primary cause of morbidity and mortality. Pulmonary ...


Study of Efficacy Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia

To determine the effect of canakinumab versus placebo on daily pain experienced by sickle cell anemia patients (Reduction of average daily pain VAS over the period of Week 8 to 12 as compared to baseline levels).


A Study of IMR-687 in Healthy Adult Volunteers

The purpose of this Phase 1a, first in human, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, PK and PD profile of the orally administered IMR-687 in healthy adult subjects.


Dose-Escalation Study of SCD-101 in Sickle Cell Disease

This is single site, dose- escalation study of SCD-101 in participants with homozygous sickle cell disease (S/S) or S/beta 0 Thalassemia. All participants will be monitored for safety, tolerability, and dose-limiting toxicities. The study is divided into two parts. Part A is an open-label, non-randomized, non-placebo-controlled dose escalation study with ...