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Heart Valve Disease Clinical Trials

A listing of Heart Valve Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (139) clinical trials

The CARILLON Trial - Transcatheter Treatment of Functional Mitral Regurgitation

A total of 400 subjects will be randomized at up to 50 investigational sites in the United States, Canada, Europe and Australia. Subjects will be randomized into one of two study groups using a 2:1 (Intervention : Control) ratio. Study subjects who are eligible for this clinical study will undergo ...

Phase N/A

Phono- and Electrocardiogram Assisted Detection of Valvular Disease

Phono- and Electrocardiogram Assisted Detection of Valvular Disease (PEA-Valve Study) Specific aim(s) Aim 1: Can a machine learning algorithm derived from simultaneous phono- and electrocardiogram recordings reliably diagnose clinically important aortic stenosis? Aim 2: Can a machine learning algorithm derived from simultaneous phono- and electrocardiogram recordings reliably diagnose clinically important ...

Phase N/A

Characterization of Endocarditis to Streptococci and Impact of the CMI on the Future of the Patients

The infectious endocarditis is a grave infection the incidence of which is at present esteemed at 30-100 episodes by million inhabitants a year. This infection is marked with a heavy morbi-mortality.Preliminary studies seem to show an abnormally high death rate at the patients presenting an infectious endocarditis to streptococci with ...

Phase N/A

The TransCatheter Valve and Vessels Trial

Prospective, randomized, controlled, open label, multicenter, international, non-inferiority trial If the Heart Team decides that a coronary revascularization and aortic valve replacement is needed and the patient complies with inclusion and exclusion criteria then the patient will be randomized in a 1:1 fashion between FFR-guided PCI + TAVI and CABG ...

Phase N/A

Improving Mitral Repair for Functional Mitral Regurgitation

Functional mitral regurgitation (FMR) is a common heart valve lesion that is observed in patients suffering for cardiomyopathies. Timely surgical repair of FMR can reduce volume overload and potentially improve cardiac function. Durable surgical techniques for FMR repair are lacking. Undersizing mitral annuloplasty (UMA) is the current technique of choice, ...

Phase N/A

Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol

The objective of this investigation is to compare the cardioprotective effects and safety of two cardioplegic solutions, HTK Cardioplegic Solution (Custodiol) and Custodiol-N in patients undergoing aortic valve surgery. The study design is a prospective, double blind, multicenter, randomized, Phase III comparison study intended to demonstrate superiority in surgical outcome ...

Phase

Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation

The trial consists of two cohorts: Cohort A, patients without an indication for OAC prior to TAVI. Cohort B, patients with an indication for OAC prior to TAVI (eg. atrial fibrillation, mechanic mitral valve prosthesis).

Phase

PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients

The PREPARE-MVR (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) Study aims to evaluate those preoperative factors which can predict the early postoperative right ventricular failure or determine the functional shift seen in right ventricular function after mitral valve replacement/repair. The PREPARE-MVR study focuses mainly on ...

Phase N/A

Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating ...

Phase N/A

Antiarrhythmic and Cardioprotective Effects of Atorvastatin Versus Magnesium Sulfate in Cardiac Valve Replacement Surgery

Arrhythmia is a common complication after cardiac valve surgery. Postoperative atrial fibrillation (POAF) is the most common type of arrhythmia after cardiac surgery. It has different leading causes, including myocardial injury, inadequate myocardial protection, the effect of cardiopulmonary bypass, and electrolyte imbalance. Beta blockers, amiodarone, and magnesium sulfate are used ...

Phase