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Diabetes Mellitus, Type 2 Clinical Trials

A listing of Diabetes Mellitus, Type 2 medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (1065) clinical trials

Efficacy and Safety Comparative Study of Sitagliptin Vildagliptin and Saxagliptin

The purpose of this study is to explore the differences in efficacy and safety of sitagliptin,vildagliptin and saxagliptin and to find which one is more better in treating type 2 diabetes mellitus.

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NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Purpose and rationale The purpose of this study is to evaluate the effect of high dose Renin-Angiotensin System (RAS)-antagonists and beta-blocker treatment for the primary prevention of cardiac events in a population of patients with Type 2 diabetes mellitus (T2DM) with no evidence of a preexisting cardiac disease. An additional ...


Saxagliptin and Cardiac Structure and Function

The cardiovascular safety and potential cardioprotective effects of diabetes drugs have been the focus of recent research. Currently, the Food and Drug Administration (FDA) requires all new anti-diabetic drugs to demonstrate no important increase in cardiovascular adverse events before approval. Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are oral incretin-based agents that ...


Canagliflozin-Mealtime Insulin Rescue

The Canagliflozin Mealtime Insulin Rescue study will enroll up to 40 subjects at the Atlanta VA Medical Center. Subjects will be screened and enter a 2-week run-in period during which they will switch to or continue on a diabetes treatment regimen of basal insulin before supper and aspart insulin before ...


Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes

Impaired muscle strength has been reported in subjects with type 1 and type 2 diabetes as a late complication of severe diabetic peripheral neuropathy (DPN). However, reduction of muscle strength has been shown to occur earlier in the course of diabetes, independent of DPN. Individuals with diabetes also show an ...

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Anti-inflammatory Effects of the Fiber

Baseline labs include complete blood count (CBC), comprehensive metabolic panel (CMP), Hemoglobin A1C, and lipid profile. All labs will be drawn in the fasting state Visit 1: Subjects will arrive after having fasted overnight (10 hours) at 7 to 7:30 am. An indwelling intravenous cannula will be placed in the ...

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Cystic Fibrosis - Insulin Deficiency Early Action

As well as progressive lung disease, patients with Cystic Fibrosis (CF) suffer pancreatic destruction, leading to slow but progressive insulin deficiency. Deficiency of insulin, a powerful anabolic hormone, causes accelerated decline of weight and lung function (important predictors of early mortality in CF). We analysed Oral Glucose Tolerance Tests sampled ...


Home-based Proprioceptive Neuromuscular Facilitation for Subjects With Type 2 Diabetes Mellitus

In this research work, the concept of strengthening technique of proprioceptive neuromuscular facilitation (PNF) incorporated with tendon gliding exercise (TGE) will be used to improve neuromuscular function of upper extremity of patients with diabetes mellitus. The first specific aim of the study is to examine the effects of home-based PNF ...

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Defining the Physiological Mechanisms of Risk Genes for Hyperglycaemia Insulin Resistance and Type 2 Diabetes

Note: The study will utilize an adaptive study design with an interim analysis at 40 volunteers (20 v 20) with the possibility of adding an additional 20 volunteers to the study (10 v 10) if the criteria for futility or clear effect are not met. The criteria are; stop and ...

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A Psychological-behavioral Intervention to Increase Activity in Type 2 Diabetes

The investigators will compare a combined positive psychology and motivational interviewing (PP-MI) intervention that is adapted for patients with T2D to a diabetes education intervention. The MGH Diabetes Center and MGH primary care clinics will serve as the source of subjects for the study, with patients who have a diagnosis ...

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