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Diabetes Mellitus, Type 1 Clinical Trials

A listing of Diabetes Mellitus, Type 1 medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (23) clinical trials

Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes With a FRC Extension Period

The maximum duration for GLP1-RA patients will be approximately 29 weeks: an up to 2 week screening period, a 26 week treatment period (either randomized or uncontrolled), and a 3 or 9 day post-treatment safety followup period. Maximum duration for FRC patients will be approximately 55 weeks: an up to ...

Phase

A Phase 2 Multicentre Randomized Double-blind Placebo-controlled Study in Patients With New-onset Type 1 Diabetes

T1D is an organ-specific autoimmune disease in which the immune system attacks the insulin-producing -cells. The onset of the disease typically occurs before adulthood and seriously affects a person's quality of life. T1D is treated with life-long daily exogenous insulin injections and monitoring of blood glucose levels. However, even optimization ...

Phase

A Study of SIMPONI to Arrest Beta-cell Loss in Type 1 Diabetes

The primary purpose of this study is to determine if golimumab can preserve beta-cell function in children and young adults with newly diagnosed Type 1 Diabetes (T1D).

Phase

Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study

Investigators intend to transplant 4 Type 1 Diabetes mellitus patients with compromised vision in one or both eyes due to diabetic or other complications, and who have already received kidney transplantation (i.e., already on immunosuppression). Transplantation of allogeneic pancreatic human islets will be performed into the anterior chamber of a ...

Phase N/A

Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin

Up to 34 weeks, including a Screening Phase of up to 2 weeks, a 2 week Run-In Phase, a 26-week double-blind Treatment Period and a 4-week post-treatment Follow-up Period to collect safety information.

Phase

Gan & Lee Insulin Glargine Target Type (1) Evaluating Research

Primary Objective: To demonstrate equivalence of Gan & Lee Pharmaceuticals insulin glargine and Lantus in terms of immunogenicity and efficacy Secondary Objectives: Immunogenicity: To evaluate the percentage of subjects with negative anti-insulin antibodies (AIA) at baseline who develop confirmed positive AIA up to Week 26

Phase

Assessment of Mealtime Bolus Insulin Behavior

The main purpose of this study is to estimate missed bolus insulin doses in diabetics. This is a 12-week, single-arm, outpatient, exploratory study with two study periods in Type 1 or Type 2 diabetics, with an investigational reusable injection pen, insulin, and a Continuous Glucose Monitoring (CGM) device.

Phase N/A

A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients

(T1D) Type 1 diabetes afflicts nearly 2 million people in the United States, most of them children or young adults(1). Untreated, it is a fatal disease. Exogenous insulin, administered by multiple injections or by a continuous subcutaneous (SC) infusion from a wearable pump, allow long term survival in those who ...

Phase

Repository of Novel Analytes Leading to Autoimmune Inflammatory and Diabetic Nephropathies (RENAL AID)

RENAL AID is designed as an inclusive data and tissue repository that is capable of linking demographic, clinical, laboratory, histology, genetic and radiographic data into one interconnected electronic data collection instrument. It is hypothesized that by linking these typically disconnected data components into a single electronic repository, RENAL AID will ...

Phase N/A

Research Study Comparing Insulin Degludec to Insulin Detemir Together With Insulin Aspart in Pregnant Women With Type 1 Diabetes

The investigators are doing this study to see the effect of insulin degludec in pregnant women with type 1 diabetes, and if it is safe to use. In this study the medicine insulin degludec is compared to another medicine called insulin detemir. Participants will either get insulin degludec or insulin ...

Phase