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Diabetes Mellitus, Type 1 Clinical Trials

A listing of Diabetes Mellitus, Type 1 medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (27) clinical trials

Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol

Pancreatic islet transplantation offers a minimally invasive approach to restore normoglycemia in type 1 diabetics while avoiding the hypoglycemic complications observed with intensive insulin therapy and the surgical complications associated with pancreas transplantation. Although significant progress has been made in clinical islet transplantation, overall outcomes remain suboptimal since many patients ...


PolyTreg Immunotherapy in Islet Transplantation

BACKGROUND Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic beta ()-cells, resulting in absolute deficiency of insulin. To date, clinical islet transplantation is an accepted modality to treat select patients who exhibit frequent hypoglycemic events and severe glycemic liability. The "Edmonton Protocol" became ...


Injectable Collagen Scaffold Combined With HUC-MSCs for the Improvement of Erectile Function in Men With Diabetes

The intent of this clinical study is to answer the questions: 1) is the proposed treatment feasible; 2) is treatment effective in improving the disease pathology of patients with diagnosed diabetic erectile dysfunction.


A Study of Glucagon Nasal Powder in Participants With Type 1 Diabetes Mellitus

The purpose of this study is to compare a needle-free treatment of hypoglycemia with glucagon nasal powder (study drug) to a marketed glucagon administered by the intra-muscular (IM) route, in participants with type 1 diabetes mellitus (T1DM).


Study of IMCY-0098 in Patients With Recent Onset Type 1 Diabetes

This clinical study will evaluate the safety of an innovative approach expected to be disease-modifying by stopping the auto-immune-mediated destruction of islet -cells in the pancreas. Three doses of the investigational product will be tested in successive cohorts. Although safety is the first objective of this study, we will gather ...


Neuropeptide Therapy of Recent Onset Type 1 Diabetes

This study evaluates the delivery of substance P via the celiac artery in the treatment of recent onset type 1 diabetes.


Feasibility Study of DermGEN for Diabetic Foot Ulcer Treatment

This will be a one-arm prospective study. This study in Halifax will be mirrored in one other participating health care center in Toronto, Ontario, Canada with each centre anticipated to enrol 5-10 patients for a total of 15-20 patients.


Enhanced Epidermal Antigen Specific Immunotherapy Trial -1

Type 1 Diabetes is caused by the body's own white blood cells damaging the insulin producing cells in the pancreas. The aim is to develop a treatment that can slow or stop this process by switching off the white blood cells causing the damage. The aim of this study is ...


Comparison of Sotagliflozin Prototype Tablets With Reference Tablet in Healthy Subjects

Total duration is 37 to 75 days for each subject, with 2 to 21 days screening period; 4 dosing days, i.e. one in each of the 4 treatment periods. Observation period in each treatment period is 6 days. Washout between dosing days is 7 to 10 days. Follow-up visit is ...


A Study of LY900014 in Elderly and Younger Adult Participants With Type 1 Diabetes Mellitus

The purpose of this study is to compare LY900014 with insulin lispro in elderly and younger adults with type 1 diabetes mellitus. Screening is required within 28 days prior to the start of the study. For each participant, the total duration of the clinical trial will be between 3 to ...