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Periodontitis Clinical Trials

A listing of Periodontitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (98) clinical trials

The objective of this study is to assess the safety and tolerability of the study drug given orally twice daily for 28 days. The study will also assess the effects of study drug on oral and cerebrospinal fluid biomarkers. The study evaluations include 2 detailed dental examinations and 2 lumbar ...

Phase

Acute-phase Response & Periodontal Treatment in Obese Patients

Periodontal treatment, consisting in both supra- and sub-gingival mechanical instrumentation of the root surface (scaling and root planing), will be performed by a single periodontist on obese patients with periodontitis. The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms ...

Phase N/A

Effects of Periodontal Treatment on HIV-infected Patients

Investigators will develop one quasi-experimental study in HIV patients (N=15) and non-HIV patients (N=15) presenting CP. Candida spp count and salivary and gingival crevicular fluid concentrations of histatin, lactoferrin, interleukin-1, interleukin-6, and tumor necrosis factor- will be determined at baseline, 30 and 90 days after the periodontal treatment. In order ...

Phase N/A

Effect of Periodontal Care on Rhematoid Arthritis in Uganda

RESEARCH QUESTIONS What is the prevalence of periodontitis among rthematoid arthritis patients attending the Mulago rheumatology clinic? Does non-surgical treatment for periodontitis improve the disease activity score in 28 joints of rheumatoid arthritis in this local setting? 2. Problem statement It has been shown that intervention with nonsurgical treatment of ...

Phase N/A

Periodontal and Cardiovascular Diseases Project

Design: randomized clinical trial, parallel design, double blinded. Sample: 120 patients from the Cardiology Department of Hospital Severo Ochoa (Legans, Madrid) suffering from established cardiovascular disease and generalized moderate/severe periodontitis. Sixty patients will be randomized to test group (scaling and root planing + systemic antimicrobials), and the other 60 subjects ...

Phase N/A

Photodynamic Therapy Plus Root Debridement in Gum Disease Treatment V2

The study will be a single centre, examiner masked, two arm, split mouth, randomized controlled clinical trial, to evaluate the clinical effectiveness of mechanical cleaning (RSD) plus additional use of a light activated dye (photodynamic therapy-PDT) compared to mechanical cleaning alone, in the treatment of residual pockets, in patients with ...

Phase N/A

Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients

Diabetes Mellitus is a risk factor for periodontal disease increasing its prevalence, extension and severity. Periodontal disease is considered the sixth complication of diabetes. There is a global epidemic of diabetes, including an increase of type 1 diabetes incidence in younger patients. Adjuvant treatments to scaling and root planing as ...

Phase N/A

Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

This protocol is a cross sectional study designed to investigate the clinical, microbiologic, and immunologic consequences of immune dysfunction (particularly dysfunction due to primary immune defects) in the oral cavity. The hypothesis is that systemic immune dysfunction, attributed to monogenic immune defects in most of our populations of interest, will ...

Phase N/A

IFI16 is a Periodontitis Modulating Protein

A total of 72 subjects will be enrolled. Specifically, a sufficient number of adults 18 years and older will be screened until 36 healthy (PPC-A) subjects and 36 subjects with severe periodontal disease (PPC-G) will be enrolled. Eligibility for study participation will be determined during the screening session. Barring dropout, ...

Phase N/A

Acute-phase Response & Periodontal Treatment in Patients With Hypertension

Periodontal treatment, consisting in both supra- and sub-gingival mechanical instrumentation of the root surface (scaling and root planing), will be performed by a single periodontist on patients with periodontitis and hypertension. The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in ...

Phase N/A