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Brain Tumor Clinical Trials

A listing of Brain Tumor medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (222) clinical trials

Topotecan in Treating Patients With Refractory or Progressive Primary Malignant Brain Tumors

OBJECTIVES: - Evaluate the safety and effectiveness of convection enhanced delivery (intracerebral clysis [ICC]) therapy comprising topotecan hydrochloride in patients with refractory or progressive primary malignant brain tumors. - Apply advanced MRI as a noninvasive means of optimizing treatment parameters and determining volume of drug distribution with convection enhanced delivery. ...


Side Effects of Radiation Therapy in Young Patients With CNS Tumors

OBJECTIVES: Primary - Assess changes in angiogenesis associated with radiotherapy of the CNS by measuring angiogenic markers in blood and urine (e.g., vascular endothelial growth factor [VEGF], basic fibroblast growth factor [bFGF], thrombospondin, tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-12, IL-8, and matrix metalloproteinases [MMPs]), and by measuring brain imaging ...

Phase N/A

Enzastaurin and Carboplatin in Treating Patients With Recurrent or Refractory Primary Brain Tumors

OBJECTIVES: Primary - Determine the maximum tolerated dose of enzastaurin hydrochloride when administered with carboplatin in patients with recurrent or refractory primary brain tumors. - Determine the pharmacokinetics of this regimen in these patients. Secondary - Correlate clinical outcome with GSK3-b activation in peripheral blood mononuclear cells of patients treated ...


Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia

OBJECTIVES: - Identify cancer patients who are low-risk inpatients and meet criteria for early discharge (i.e., symptomatic improvement and temperature ≤ 37.8°C) after receiving oral antibiotics for febrile neutropenia. OUTLINE: This is a randomized, prospective, multicenter study. Patients are stratified by disease type (lymphoma vs solid tumor), duration of registration ...


Study of Patients With Cancer or Precancerous Conditions

OBJECTIVES: - To follow and evaluate patients, longitudinally with cancer or precancerous conditions referred to the NIH Clinical Center Pediatric Oncology Branch who present with disease manifestations that lend themselves to clinical evaluation and are of unique scientific importance. - To allow, when clinically indicated, patients to receive standard care ...

Phase N/A

Natural History Study of Patients With Central Nervous System Tumors Being Evaluated at the National Institutes of Health

OBJECTIVES: - Evaluate patients with CNS tumors who are probable future candidates for NCI phase I and II protocols. - Follow patients with CNS tumors that are representative of important scientific and/or clinical principles. - Attain a steady flow of patients with CNS tumors at the NIH, which will help ...

Phase N/A

Collecting and Storing Information From Patients With Cancer or Other Chronic Disease Who Have Undergone Neurobehavioral Assessments on Another Clinical Trial

OBJECTIVES: Primary - Determine the neurobehavioral function of patients with chronic illness by analyzing stored data collected from IRB-approved protocols comprising retrospective data collected on protocols that are now closed and prospective data from current and future protocols. Secondary - Determine the relationship between neurobehavioral functioning and medical, neuroimaging, neurologic, ...

Phase N/A

Stereotactic Radiosurgery to the Resection Cavity Following Surgical Removal of Brain Metastasis

Study Purpose Treatment strategies for recurrent brain metastasis Limited clinical data support interventions for recurrent BM such as WBRT, re-operation or SRS, depending on previous treatments (6, 45, 48). Two retrospective analyses looked at a total of 130 non-small cell lung cancer (NSCLC) patients with recurrent BM after resection (6, ...