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Brain Tumor Clinical Trials

A listing of Brain Tumor medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (222) clinical trials

Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

BACKGROUND - Preliminary data generated from our pilot protocol 02-C-0064 suggests that the urinary VEGF and MMP level at the one month follow-up time point compared to the last on-treatment time point collection may be predictive of tumor recurrence at one year (l). - Note that this preliminary study included ...

Phase N/A

Carboplatin Melphalan Etoposide Phosphate Mannitol and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors

PRIMARY OBJECTIVES: I. To evaluate toxicity and estimate the maximum tolerated dose (MTD) of melphalan (intra-arterially [i.a.]) administered in conjunction with carboplatin (i.a.) and etoposide phosphate (intravenously [i.v.]) undergoing BBBD, in subjects with anaplastic oligodendroglioma or oligoastrocytoma. (Phase I) II. To examine the efficacy (one year progression free survival [1YPFS]) ...


Imaging Study in Patients With Cancer of the Head & Neck Lung Renal Cell Brain Lymphoma and Neuroendocrine Tumours

The proposed clinical trial will be a Phase I/II imaging, open label, single site study. In Phase I, one 18F-FAZA PET scan will be conducted in patients with known squamous cell carcinoma of the Head & Neck, SCLC, NSCLC, lymphoma, GGM, neuroendocrine tumours or renal cell carcinoma. In Phase II, ...


Topotecan in Treating Patients With Refractory or Progressive Primary Malignant Brain Tumors

OBJECTIVES: - Evaluate the safety and effectiveness of convection enhanced delivery (intracerebral clysis [ICC]) therapy comprising topotecan hydrochloride in patients with refractory or progressive primary malignant brain tumors. - Apply advanced MRI as a noninvasive means of optimizing treatment parameters and determining volume of drug distribution with convection enhanced delivery. ...


Side Effects of Radiation Therapy in Young Patients With CNS Tumors

OBJECTIVES: Primary - Assess changes in angiogenesis associated with radiotherapy of the CNS by measuring angiogenic markers in blood and urine (e.g., vascular endothelial growth factor [VEGF], basic fibroblast growth factor [bFGF], thrombospondin, tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-12, IL-8, and matrix metalloproteinases [MMPs]), and by measuring brain imaging ...

Phase N/A

Enzastaurin and Carboplatin in Treating Patients With Recurrent or Refractory Primary Brain Tumors

OBJECTIVES: Primary - Determine the maximum tolerated dose of enzastaurin hydrochloride when administered with carboplatin in patients with recurrent or refractory primary brain tumors. - Determine the pharmacokinetics of this regimen in these patients. Secondary - Correlate clinical outcome with GSK3-b activation in peripheral blood mononuclear cells of patients treated ...