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Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (44) clinical trials

Molecular-Guided Therapy for Childhood Cancer

The purpose of this study is to test the feasibility (ability to be done) of experimental technologies to determine a tumor's molecular makeup. This technology includes a genomic report based on DNA exomes and RNA sequencing that will be used to discover new ways to understand cancers and potentially predict ...

Phase N/A

A Novel Single Arm Phase II Study for Relapsed Germ Cell Tumours With Poor Prognosis

Patients will receive a 4 drug combination chemotherapy in hospital over two nights. On the third day, the patient will receive an injection of pegfilgrastim. This stimulates the bone marrow to produce white blood cells and shortens the period of risk of serious infection. The treatment will be repeated every ...


Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors

OBJECTIVES: - Compare progression-free survival rates of patients with poor prognosis stage II or III non-seminomatous germ cell tumors with an unfavorable decrease of tumor markers after treatment with 1 course of bleomycin, etoposide, and cisplatin followed by subsequent treatment with 3 additional courses of bleomycin, etoposide, and cisplatin OR ...


Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

OBJECTIVES: I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions. II. Provide a repository for long-term storage of specimens from these patients. III. Make these specimens available to qualified researchers to understand the biology of pediatric brain ...

Phase N/A

Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors

OBJECTIVES Primary Determine overall survival (OS) of patients with germ cell tumors treated with tandem autologous stem cell transplantation with non-cross-resistant conditioning regimens. Secondary Determine disease-free survival (DFS) of patients treated with this regimen. Determine the toxicity of tandem transplants Determine the time to engraftment of neutrophils and platelets in ...


Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01

OBJECTIVES: - Determine the late effects of treatment and the quality-of-life of patients with germ cell tumors (GCT) previously treated on clinical trial CCLG-GC-1979-01 or CCLG-GC-1989-01. - Evaluate the late effects of carboplatin, etoposide, and bleomycin in patients treated on clinical trial CCLG-GC-1989-01. - Determine the toxicity of bleomycin and ...

Phase N/A

Evaluating Immune Therapy Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

The purpose of this study is to test the safety and effectiveness of durvalumab with tremelimumab in patients with relapsed or refractory germ cell tumors.


NAC to Prevent Cisplatin-induced Hearing Loss

The study is a dose-finding study of N-acetylcysteine (NAC) to protect hearing in children receiving cisplatin for the treatment of their cancer. NAC also has potential to protect the kidneys from cisplatin toxicity. The study uses a 3+3 dose-escalation scheme to determine the dose of NAC necessary to achieve serum ...


A clinical trial sponsored by National Cancer Institute (NCI) for a research study for the treatment of Mesothelioma, Thymoma, Germ cell tumor, Esophageal Cancer, Lung Neoplasm

Background Increasing evidence indicates that activation of stem cell gene expression is a common mechanism by which environmental carcinogens mediate initiation and progression of thoracic malignancies. Similar mechanisms appear to contribute to extra-thoracic malignancies that metastasize to the chest. Utilization of pharmacologic agents, which target gene regulatory networks mediating stemness ...


Study of Genistein in Pediatric Oncology Patients (UVA-Gen001)

This is a multi-center, randomized, double blind, placebo-controlled crossover study to evaluate the effect of soy isoflavones on the short term untoward effects of myelosuppressive chemotherapy used to treat pediatric cancers. Newly diagnosed cancer patients aged 1-21 years will be registered to the study and informed consent will be obtained ...