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Metabolic Syndrome Clinical Trials

A listing of Metabolic Syndrome medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (174) clinical trials

Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation

Nutritional epigenetics denotes gene-diet interactions and highlights the modulatory role of nutrition in aging and age-related diseases such as cancer, CVD (cardiovascular disease), diabetes and neurodegenerative disorders. Nutrients are a source of epigenetic modification; they are able to regulate the placement of histone modifiers distinguishing phenotype from genotype. The energy ...

Phase N/A

Prebiotics in Patients With Non-alcoholic Liver Disease

The study will include 60 patients with Non-alcoholic fatty liver disease (NAFLD) which will randomize to two groups, receiving either ITF (Inulin/oligofructose-OFS 75/25) or maltodextrin (placebo). The trial will last for 20 weeks: Stage 1-Run-in period: Subjects will be followed to ascertain weight maintenance. Stage 2- Randomized intervention period: Subjects ...

Phase N/A

Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism

In aim 1 subjects are randomized to cross over between an 8 day high salt and 8 day low salt diet and assessments are made. In aim 2, subjects are randomized to a 2x2 cross over study with an 8 day low salt diet and either eplerenone 50mg or amlodipine ...

Phase N/A

Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

Objective To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma. Methods 234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

Phase N/A

Blood Lipopolysaccharide (LPS) Rifaximin Study

This is a randomized, placebo controlled proof of concept study that will examine the investigational drug Rifaximin Soluble Solid Dispersion (SSD) ability to reduce gut microbiota and thereby reduce adipose inflammation and improve insulin resistance. Each subject enrolled will undergo a fat tolerance test with a high fat meal, an ...


Effect of Dietary Habits on Metabolic Health

More than a third of U.S. adults are obese (BMI greater than 30), 8-12% of adults suffer from type 2 diabetes, and up to 30% of adults have pre-diabetes. Recent research studies have suggested that it is not just what we eat, but also when we eat that may put ...

Phase N/A

Medical and Physiological Benefits of Reduced Sitting

The most important objective of this randomized controlled trial in subjects with increased cardiovascular and metabolic risk factors is to investigate whether only reduced daily sitting improves human cardiovascular and metabolic health during a six-month intervention. It is hypothesized and expected that only reduced sitting, without formal physical activity or ...

Phase N/A

Effects of a Calorie Restricted Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health

Reduced energy intake and increased physical activity have profound effects on cardiometabolic health as assessed by insulin sensitivity, -cell function, serum lipids, intra-abdominal fat mass, intrahepatic triglyceride content, and blood pressure, and is the cornerstone of treatment for people with obesity. However, the specific additional therapeutic effects of regular exercise ...

Phase N/A

Study of the Safety Tolerability and Efficacy of Metabolic Combination Treatments on Cancer

This is a real world study since this gives the best opportunity to properly examine the effect of multi-drug regimens in representative populations. Including a standard of care arm is inappropriate, in a population in which that standard of care has already been shown to be ineffective or intolerable. Patients ...


Effects of Short-term Interventions for a Healthy Lifestyle on the Human Lipidome in Subjects With Metabolic Syndrome

A growing number of cross-sectional studies is investigated the role of the human lipidome as a new biomarker for metabolic diseases. However, data on this issue is still sparse and especially interventional data is not available up to now. We intend to clarify, if the human lipidome is correlating with ...

Phase N/A