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Adenocarcinoma Clinical Trials

A listing of Adenocarcinoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (94) clinical trials

A clinical research study of Triapine, Cisplatin

PRIMARY OBJECTIVES: I. To evaluate the efficacy of the experimental regimen of triapine (3AP), cisplatin, and radiation to increase progression-free survival relative to the standard/control regimen of cisplatin and radiation in women with uterine cervix and vaginal cancer. SECONDARY OBJECTIVES: I. To determine the post-therapy 3-month fludeoxyglucose F-18 (18F-FDG) positron ...


A clinical trial sponsored by Alliance for Clinical Trials in Oncology for a research study for the treatment of Ductal Carcinoma In Situ, Breast Cancer

This randomized controlled trial of weight loss interventions in overweight and obese women with early stage breast cancer consists of two arms, please see the arms section for more information. Patients will be randomized 1:1 within stratification factors: menopausal status (premenopausal vs. postmenopausal), hormone receptor status of the tumor (ER ...


A clinical trial seeking patients for a research study for the treatment of Lung Adenocarcinoma, Lung Neoplasm

Background EGFR tyrosine kinase inhibitors (TKI) have significantly improved the response rate (RR) and survival in patients with tumors harboring EGFR-sensitizing mutations. An invariable consequence of treatment with EGFR-TKIs is the development of acquired resistance. The most common mechanism of resistance observed in approximately 50% of all cases is the ...


Nivolumab in Treating Patients With High-Risk Non-Metastatic Kidney Cancer

PRIMARY OBJECTIVES: I. To study the safety and feasibility of neoadjuvant nivolumab administration in subjects with resectable, high-risk, non-metastatic renal cell carcinoma. SECONDARY OBJECTIVES: I. To assess overall response rate in patients receiving neoadjuvant nivolumab. II. To assess recurrence free survival at 2 years in patients receiving neoadjuvant nivolumab. TERTIARY ...


A clinical research study for the treatment of Renal Cell Carcinoma

This will be a single arm, multi-site phase Ib/II clinical trial of standard doses of High Dose Interleukin-2 (HD IL2) (600,000 IU/kg/dose intravenously during two 5-day cycles 9 days apart) in IL-2 eligible clear cell metastatic RCC (Renal Cell Carcinoma) subjects in combination with Nivolumab. Investigators hypothesize that concurrent PD-1 ...


A clinical trial sponsored by Sidney Kimmel Cancer Center at Thomas Jefferson University for a research study for the treatment of Ductal Carcinoma In Situ, Uterine Corpus Cancer, Uterine Corpus Carcinosarcoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Breast Cancer

PRIMARY OBJECTIVES: I. To determine if treatment with a combination of metformin and doxycycline can increase the percentage of cells that express Caveolin-1 in the cancer associated fibroblasts of patients with breast, or uterine, and cervical cancers. SECONDARY OBJECTIVES: I. To determine the effect of metformin and doxycycline treatment on ...


Phase I/Ib Study of Pembrolizumab With Vorinostat for Patients With Advanced Renal or Urothelial Cell Carcinoma

This is a Phase I/Ib, open-label, safety, and pharmacodynamics study of pembrolizumab in combination with vorinostat in patients with advanced renal or urothelial cell carcinoma. This clinical study will be composed of a Dose Finding Phase and an Expansion Phase. The Dose Finding Phase will estimate the Recommended Phase II ...


A Phase 3 clinical study for patients with Stage III Renal Cell Cancer AJCC v7, Unclassified Renal Cell Carcinoma, Renal Cell Carcinoma, Stage II Renal Cell Cancer AJCC v7

PRIMARY OBJECTIVES: I. To compare recurrence-free survival (RFS) between patients with locally advanced renal cell carcinoma randomly assigned to perioperative nivolumab in conjunction with radical or partial nephrectomy with patients randomized to surgery alone. SECONDARY OBJECTIVES: I. To evaluate for differences in recurrence-free survival associated with perioperative nivolumab compared to ...


A clinical trial seeking patients for a research study of S-1, Nivolumab, Oxaliplatin, Andecaliximab, Cisplatin

The primary objective of this study is to characterize the safety and tolerability of andecaliximab (GS-5745) as monotherapy and in combination with anti-cancer agents in Japanese participants with inoperable advanced or recurrent gastric or recurrent gastroesophageal junction (GEJ) adenocarcinoma.