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Cystic Fibrosis Clinical Trials

A listing of Cystic Fibrosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (131) clinical trials

Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis

Background The main risk factor for cervical cancer is the infection by human papillomavirus (HPV), with several intermediate steps between HPV infection and cervical cancer. Cervical screening with pap smear test and HPV vaccination are effective preventions. A high frequency of HPV carriage and of cervical dysplasia have been described ...

Phase N/A

Airway Clearance System (K031876) Phase IV Device Efficacy

Phase IV interventional study, of participants with cystic fibrosis with mild, moderate or severe conditions, for the efficacy of the Electro Flo Percussor, Model 5000 (K031876), Regulation Number: 21 CFR 868.5665, with current FDA indication of: provide airway clearance therapy when external manipulation of the thorax is the physician's choice ...

Phase N/A

Ivacaftor (Kalydeco) and Insulin in Cystic Fibrosis (CF)

Cystic Fibrosis Related Diabetes (CFRD) is associated with worse nutritional status, greater pulmonary function decline, and increased mortality, highlighting its relevance in Cystic Fibrosis (CF). CFRD arises primarily from compromised insulin secretion - traditionally considered a by-product of pancreatic exocrine tissue damage and fibrosis. Recent developments in the field of ...

Phase N/A

Inflammatory Markers in Broncho-alveolar Lavage Fluid as Risk Factors for Lung Disease in Infants With Cystic Fibrosis: the I-BALL Study

Rationale: Airway disease, featuring early and intense inflammation and leading to progressive lung damage, is the main cause of morbidity and mortality in cystic fibrosis (CF). Mechanisms of CF airway inflammation remain unclear, hampering development of better treatments. Recent introduction of heel-prick screening for CF provides a unique longitudinal cohort ...

Phase N/A

PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis

No nontuberculosis mycobacteria (NTM) treatment protocol has been validated in the setting of cystic fibrosis (CF). This trial tests the feasibility of a standardized treatment algorithm for confirmed disease by either M. avium complex or the M. abscessus complex that is also based on forthcoming guidelines from the CF Foundation ...

Phase N/A

High Resolution Micro OCT Imaging

Lung Disease is the predominate cause of morbidity and mortality in patients with cystic fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order to reveal the features that may lead to the onset of progressive lung disease. Discerning the nature of the CF defect ...

Phase N/A

PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis

Isolation of an nontuberculous mycobacteria (NTM) from sputa of cystic fibrosis (CF) patients is relatively common, and of uncertain significance. At the request of the CF Foundation (CFF), the Investigators have designed a standardized diagnostic protocol based on current recommendations for the diagnosis of NTM by the American Thoracic Society, ...

Phase N/A

The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation

Background: Elastin is a unique protein providing elasticity, resilience and deformability to dynamic tissues, such as lungs and vasculature. Elastin fibers are characterized by their high affinity for calcium. However, calcified elastin is more prone to the degrading effects of proteases and, in turn, partially degraded elastin has an even ...

Phase N/A

Multiple Breath Washout a Clinimetric Dataset

Lung Clearance Index (LCI) has been shown to be more sensitive and perhaps more applicable in early stages of lung disease when compared to currently utilised physiological outcome measures, and yet it is not approved by regulatory agencies as a recognised surrogate outcome measure. This may highlight some of the ...

Phase N/A

Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively

Initially, healthy volunteers will be vaccinated to be compared with patients' antibody response to hepatitis A and B vaccine. The connected part of this study is to vaccinate children suffering from latent tuberculosis against hepatitis B and to measure whether the immunization is related to specific interferon gamma response against ...

Phase N/A