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Cystic Fibrosis Clinical Trials

A listing of Cystic Fibrosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (134) clinical trials

Inflammatory Markers in Broncho-alveolar Lavage Fluid as Risk Factors for Lung Disease in Infants With Cystic Fibrosis: the I-BALL Study

Rationale: Airway disease, featuring early and intense inflammation and leading to progressive lung damage, is the main cause of morbidity and mortality in cystic fibrosis (CF). Mechanisms of CF airway inflammation remain unclear, hampering development of better treatments. Recent introduction of heel-prick screening for CF provides a unique longitudinal cohort ...

Phase N/A

PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis

No nontuberculosis mycobacteria (NTM) treatment protocol has been validated in the setting of cystic fibrosis (CF). This trial tests the feasibility of a standardized treatment algorithm for confirmed disease by either M. avium complex or the M. abscessus complex that is also based on forthcoming guidelines from the CF Foundation ...

Phase N/A

High Resolution Micro OCT Imaging

Lung Disease is the predominate cause of morbidity and mortality in patients with cystic fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order to reveal the features that may lead to the onset of progressive lung disease. Discerning the nature of the CF defect ...

Phase N/A

PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis

Isolation of an nontuberculous mycobacteria (NTM) from sputa of cystic fibrosis (CF) patients is relatively common, and of uncertain significance. At the request of the CF Foundation (CFF), the Investigators have designed a standardized diagnostic protocol based on current recommendations for the diagnosis of NTM by the American Thoracic Society, ...

Phase N/A

The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation

Background: Elastin is a unique protein providing elasticity, resilience and deformability to dynamic tissues, such as lungs and vasculature. Elastin fibers are characterized by their high affinity for calcium. However, calcified elastin is more prone to the degrading effects of proteases and, in turn, partially degraded elastin has an even ...

Phase N/A

Multiple Breath Washout a Clinimetric Dataset

Lung Clearance Index (LCI) has been shown to be more sensitive and perhaps more applicable in early stages of lung disease when compared to currently utilised physiological outcome measures, and yet it is not approved by regulatory agencies as a recognised surrogate outcome measure. This may highlight some of the ...

Phase N/A

Perceived Impact of Art Therapy in Patients With Cystic Fibrosis and in Professional Interdisciplinary Teams Taking Care of Them.

Cystic fibrosis is so far a disease whose treatment remains essentially symptomatic care teams perceive the boundaries of a support mainly focused on drug treatments. The patient had no other choice but to learn to live with their disease, the goal is to make every effort so that tames the ...

Phase N/A

Portal Hypertension and Systemic Endothelial Function

Prospective , monocentric study, with four groups of patients: Patients with cystic fibrosis and PHT Cystic fibrosis patients without PHT Patients free from cystic fibrosis with PHT from other causes Healthy controls. One study visit, no follow-up. During the visit the following examinations will be performed: Collection of a blood ...

Phase N/A

Clinical Effects of Exercise Program Added to Pulmonary Rehabilitation in Patients With Cystic Fibrosis

Cystic fibrosis (CF) is an autosomal recessive, multisystem involvement disease. The most important cause of mortality in CF is pulmonary complications. Prevention of pulmonary complications is only possible with pulmonary rehabilitation. Pulmonary rehabilitation methods used in CF are called airway cleaning techniques that include postural drainage, breathing techniques and use ...

Phase N/A

Longitudinal Pathogen-colonization in Cystic Fibrosis Airways and Ability to Smell

The sub-study on the sense of smelling in CF has been finalized in the meantime. Results were published in 2012: Smell in cystic fibrosis. Lindig J, Steger C, Beiersdorf N, Michl R, Beck JF, Hummel T, Mainz JG. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):915-21. doi: 10.1007/s00405-012-2124-2. Epub 2012 Aug 14.

Phase N/A