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Cystic Fibrosis Clinical Trials

A listing of Cystic Fibrosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (201) clinical trials

6 Minute Walk Test in Cystic Fibrosis

The 6-minute walk test is a simple exercise test, reproducing a daily physical activity. The utility of this test is described in several chronic lung diseases (chronic obstructive pulmonary disease, idiopathic pulmonary arterial hypertension). The distance performed during the 6MWT and / or desaturation during the 6MWT is a prognostic ...

Phase N/A

Symptom Score to Assess Abdominal Involvement in Patients With Cystic Fibrosis

Development of a multimodal questionnaire considering the FDA guidelines for patient reported outcome measures (PROM) Evaluation of reliability of the questionnaire by examining internal consistency and construct validity Evaluation of reproducibility of the questionnaire by re-testing of patients Assessment of cross-generational applicability of the questionnaire by sub-scoring of age groups ...

Phase N/A

A Study to Evaluate Safety Efficacy and Tolerability of TEZ/IVA in Orkambi (Lumacaftor/Ivacaftor) -Experienced Subjects With Cystic Fibrosis (CF)

Study VX16-661-114 (Study 114) is a Phase 3b, randomized, double-blind, placebo-controlled, parallel group, multicenter study in subjects aged 12 years and older with CF who are homozygous for the F508del mutation on the CFTR gene and who discontinued treatment with Orkambi due to respiratory symptoms considered related to treatment. This ...

Phase

Evaluating High Flow Humidification Therapy in Patients With Cystic Fibrosis

This study is a single center, randomized pilot study to evaluate the clinical effectiveness of nasal high flow 20LPM humidification therapy in subjects with Cystic Fibrosis.

Phase N/A

Safety Pharmacokinetics and Pharmacodynamics Study of Inhaled QBW276 in Patients With Cystic Fibrosis

This is a study of multiple doses of inhaled QBW276 in patients with cystic fibrosis on top of standard of care. The study will be divided into 3 Cohorts. Cohorts 1 and 2 are designed to be a randomized, double-blind, placebo-controlled, parallel arm, multiple dose study to assess the safety, ...

Phase

ICM to Evaluate the Activation of p.Phe508del-CFTR by Lumacaftor in Combination With Ivacaftor

Study design. This academic investigator - initiated trial will resolve the key issue whether, and if yes, to what extent and variability, the treatment with lumacaftor in combination with ivacaftor (Orkambi) will reverse the p.Phe508del CFTR - mediated basic defect in p.Phe508del homozygous subjects with cystic fibrosis under real life ...

Phase N/A

Safety and Tolerability Study of Allogeneic Mesenchymal Stem Cell Infusion in Adults With Cystic Fibrosis

This will be a prospective, single-center, dose-escalation, open-label interventional study to evaluate the safety and tolerability of allogeneic hMSCs in 15 clinically stable subjects with CF age 18 years. After a two to six week screening period, subjects will have a Baseline visit (Days 1-2) where they will undergo a ...

Phase

Chest Wall Motion Analysis in Disease

Optoelectronic plethysmography (OEP) is based on the analysis during breathing of the trajectories of a series of markers positioned on the thoracic-abdominal surface of the patient. The positions in space of these markers are recorded and processed with mathematical models and algorithms by a computing unit that can accurately measure ...

Phase N/A

A Study of Home Monitoring in Adults With Cystic Fibrosis (HOMECF)

The principal question being answered by this research study is: Does home monitoring reduce the total number of inpatient hospital days in adults with cystic fibrosis (CF) compared to routine clinical care? The secondary objectives of this research study are to assess: The effect of home monitoring on lung function ...

Phase N/A

Safety Efficacy and Feasibility of High-dose Cholecalciferol in Pediatric Patients With Cystic Fibrosis

Children and adults with Cystic Fibrosis (CF) are at risk of developing a vitamin D deficiency or insufficiency, defined as a 2,25-hydroxyvitamin D (25OHD) serum blood level <30 ng/dL. Greater than 85% of people with CF have pancreatic insufficiency, which contributes to poor absorption of fat soluble vitamins in addition ...

Phase