Search Medical Condition
Please enter condition
Please choose location from dropdown

Cystic Fibrosis Clinical Trials

A listing of Cystic Fibrosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (206) clinical trials

Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease

This study is designed to explore the efficacy and safety of nasal aztreonam administered using the Pari Sinus Nebulizer combined with oral Cayston aerosol therapy compared to placebo on clinical and laboratory endpoints such as risk of antibiotic-resistant Pseudomonas aeruginosa (PA), time to pulmonary infection exacerbation, nasal quality of life, ...

Phase

Ivacaftor (Kalydeco) and Insulin in Cystic Fibrosis (CF)

Cystic Fibrosis Related Diabetes (CFRD) is associated with worse nutritional status, greater pulmonary function decline, and increased mortality, highlighting its relevance in Cystic Fibrosis (CF). CFRD arises primarily from compromised insulin secretion - traditionally considered a by-product of pancreatic exocrine tissue damage and fibrosis. Recent developments in the field of ...

Phase N/A

Inflammatory Markers in Broncho-alveolar Lavage Fluid as Risk Factors for Lung Disease in Infants With Cystic Fibrosis: the I-BALL Study

Rationale: Airway disease, featuring early and intense inflammation and leading to progressive lung damage, is the main cause of morbidity and mortality in cystic fibrosis (CF). Mechanisms of CF airway inflammation remain unclear, hampering development of better treatments. Recent introduction of heel-prick screening for CF provides a unique longitudinal cohort ...

Phase N/A

PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis

No nontuberculosis mycobacteria (NTM) treatment protocol has been validated in the setting of cystic fibrosis (CF). This trial tests the feasibility of a standardized treatment algorithm for confirmed disease by either M. avium complex or the M. abscessus complex that is also based on forthcoming guidelines from the CF Foundation ...

Phase N/A

High Resolution Micro OCT Imaging

Lung Disease is the predominate cause of morbidity and mortality in patients with cystic fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order to reveal the features that may lead to the onset of progressive lung disease. Discerning the nature of the CF defect ...

Phase N/A

PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis

Isolation of an nontuberculous mycobacteria (NTM) from sputa of cystic fibrosis (CF) patients is relatively common, and of uncertain significance. At the request of the CF Foundation (CFF), the Investigators have designed a standardized diagnostic protocol based on current recommendations for the diagnosis of NTM by the American Thoracic Society, ...

Phase N/A

The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients

Insulin insufficiency related to pancreatic fibrosis and -cell dysfunction is present in almost every cystic fibrosis (CF) patient. Progressive abnormalities in insulin secretion begin in childhood, and, in adults, CF related diabetes (CFRD) is eventually present in more than half of the CF population. CFRD is associated with weight loss, ...

Phase

Inhaled Nitric Oxide for Cystic Fibrosis Patients With MABSC

A Prospective, Open labeled, multi-Center, Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently via Inhalation to Subjects with Cystic Fibrosis diagnosed with NTM (specifically MABSC). Nitric Oxide (NO) has been shown to play a critical role in various biological functions. In the airways, NO is considered ...

Phase

The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation

Background: Elastin is a unique protein providing elasticity, resilience and deformability to dynamic tissues, such as lungs and vasculature. Elastin fibers are characterized by their high affinity for calcium. However, calcified elastin is more prone to the degrading effects of proteases and, in turn, partially degraded elastin has an even ...

Phase N/A

Multiple Breath Washout a Clinimetric Dataset

Lung Clearance Index (LCI) has been shown to be more sensitive and perhaps more applicable in early stages of lung disease when compared to currently utilised physiological outcome measures, and yet it is not approved by regulatory agencies as a recognised surrogate outcome measure. This may highlight some of the ...

Phase N/A