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Cystic Fibrosis Clinical Trials

A listing of Cystic Fibrosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (205) clinical trials

Symptom Score to Assess Abdominal Involvement in Patients With Cystic Fibrosis

Development of a multimodal questionnaire considering the FDA guidelines for patient reported outcome measures (PROM) Evaluation of reliability of the questionnaire by examining internal consistency and construct validity Evaluation of reproducibility of the questionnaire by re-testing of patients Assessment of cross-generational applicability of the questionnaire by sub-scoring of age groups ...

Phase N/A

ICM to Evaluate the Activation of p.Phe508del-CFTR by Lumacaftor in Combination With Ivacaftor

Study design. This academic investigator - initiated trial will resolve the key issue whether, and if yes, to what extent and variability, the treatment with lumacaftor in combination with ivacaftor (Orkambi) will reverse the p.Phe508del CFTR - mediated basic defect in p.Phe508del homozygous subjects with cystic fibrosis under real life ...

Phase N/A

Chest Wall Motion Analysis in Disease

Optoelectronic plethysmography (OEP) is based on the analysis during breathing of the trajectories of a series of markers positioned on the thoracic-abdominal surface of the patient. The positions in space of these markers are recorded and processed with mathematical models and algorithms by a computing unit that can accurately measure ...

Phase N/A

A Study of Home Monitoring in Adults With Cystic Fibrosis (HOMECF)

The principal question being answered by this research study is: Does home monitoring reduce the total number of inpatient hospital days in adults with cystic fibrosis (CF) compared to routine clinical care? The secondary objectives of this research study are to assess: The effect of home monitoring on lung function ...

Phase N/A

Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis

Background The main risk factor for cervical cancer is the infection by human papillomavirus (HPV), with several intermediate steps between HPV infection and cervical cancer. Cervical screening with pap smear test and HPV vaccination are effective preventions. A high frequency of HPV carriage and of cervical dysplasia have been described ...

Phase N/A

Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis

The aim of this study is to investigate the efficacy of antibiotic therapy with any antibiotic (IV) and IV (Nebcin) tobramycin for 5 days followed by Solution for nebuliser inhalation (Tobi) for 9 days and antibiotic cures using 14 days of tobramycin IV. In the case of positive results, the ...

Phase

Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease

This study is designed to explore the efficacy and safety of nasal aztreonam administered using the Pari Sinus Nebulizer combined with oral Cayston aerosol therapy compared to placebo on clinical and laboratory endpoints such as risk of antibiotic-resistant Pseudomonas aeruginosa (PA), time to pulmonary infection exacerbation, nasal quality of life, ...

Phase

Ivacaftor (Kalydeco) and Insulin in Cystic Fibrosis (CF)

Cystic Fibrosis Related Diabetes (CFRD) is associated with worse nutritional status, greater pulmonary function decline, and increased mortality, highlighting its relevance in Cystic Fibrosis (CF). CFRD arises primarily from compromised insulin secretion - traditionally considered a by-product of pancreatic exocrine tissue damage and fibrosis. Recent developments in the field of ...

Phase N/A

Inflammatory Markers in Broncho-alveolar Lavage Fluid as Risk Factors for Lung Disease in Infants With Cystic Fibrosis: the I-BALL Study

Rationale: Airway disease, featuring early and intense inflammation and leading to progressive lung damage, is the main cause of morbidity and mortality in cystic fibrosis (CF). Mechanisms of CF airway inflammation remain unclear, hampering development of better treatments. Recent introduction of heel-prick screening for CF provides a unique longitudinal cohort ...

Phase N/A

PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis

No nontuberculosis mycobacteria (NTM) treatment protocol has been validated in the setting of cystic fibrosis (CF). This trial tests the feasibility of a standardized treatment algorithm for confirmed disease by either M. avium complex or the M. abscessus complex that is also based on forthcoming guidelines from the CF Foundation ...

Phase N/A