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Crohn's Disease Clinical Trials

A listing of Crohn's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (67) clinical trials

Anti TNF Improves Endothelial Dysfunction in IBD Patients

Crohn's Disease (CD) is a life long disease that mainly affects young adults. There is evidence That gut tissue injury is the result of an abnormal immune response that involved multiple non immune cellular systems including the intestinal microvascular endothelial cell. Moreover, clinical studies have shown that 1-7% of irritable ...


Adalimumab Trough Concentrations in Crohn's Disease: A Pilot Pharmacokinetic Study

Adalimumab (ADM), a fully human tumor necrosis factor (TNF) antagonist, is effective for treating patients with Crohn's disease (CD). A correlation between concentration and effect was observed at distinct time points. The aim was to evaluate the correlation of early longitudinal measurements of ADM with different biological markers for disease ...

Phase N/A

Bacteria & Inflammation in the Gut (BIG) Study

The null hypothesis is that the clinical response to exclusive enteral nutrition (EEN) and reduction of colonic inflammatory markers are not associated with a characteristic bacterial taxonomy (composition) and metabolites (functionality) and that maintenance of any bacterial changes with supplementary enteral nutrition (SEN), while returning to habitual diet, does not ...

Phase N/A

Predictive Factors of ANTI-TNF Response in Luminal Crohn's Disease Complicated by Abscess

Multicenter prospective observational cohort. Initial management of sepsis and abscess (Before anti-TNF therapy initiation) i. Antibiotics. ii. Percutaneous drainage will be performed every time when possible iii. Surgical drainage will be performed if percutaneous drainage is not accessible or fails iv. Concomitant medications : Steroids will be rapidly tapered and ...

Phase N/A

The Innate Immune System and Inflammatory Bowel Disease

The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands relevant for stimulation of the IIS and study the immune response. Colonic mucosal samples are examined to ...

Phase N/A

Epidemiology of IBD in Hong Kong: An Inception Cohort and Follow up Study

Investigators will create the first web-based Hong Kong inception cohort database. Via the web registration investigators intend to form a new prospective, uniformly diagnosed, population-based inception cohort of patients with IBD. Physicians, gastroenterologists, family doctors, surgeons and pathologists in our study area will be notified repeatedly about the study by ...

Phase N/A

Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission

Crohn's disease goes along with an alteration of the quality of life, even in remission and has a negative impact on stress management linked to the pain and the health. Conversely, stress and psychological variables play a significant role in the pathogenesis of this disease. These interrelations reflects the link ...

Phase N/A

MR Assessment of Perianal Crohn's Disease

Background Inflammatory Bowel Disease has the United Kingdom prevalence of ~620,000 patients. PCD is the commonest form of fistulising Crohn's disease with 20% of patients affected and with 30% of them experiencing recurring disease symptoms. Durable clinical remission rate for complex fistulas is only 37% at the end of a ...

Phase N/A

Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District Seoul Korea.

Inflammatory bowel disease (IBD), which is comprised of Crohn's disease (CD) and ulcerative colitis (UC) is a chronic inflammatory disease of gut with uncertain etiopathogenesis. According to our previous study (Yang, et al. Inflamm Bowel Dis 2008; 14: 542-549), the incidence and prevalence of IBD in Korea are still low ...

Phase N/A

Faecal Calprotectin as a Potential Non-invasive Inflammatory Marker in Pregnancy and Inflammatory Bowel Disease

Pregnancy has an interesting and different impact on inflammatory conditions that have much in common immunologically. In inflammatory bowel disease 33% will deteriorate, 33% will remain stable and 33% will improve. In rheumatoid arthritis 75% of women will improve. Gut microbiota alters significantly in pregnancy as do predominant immunological pathways ...

Phase N/A