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Leukemia (Pediatric) Clinical Trials

A listing of Leukemia (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (246) clinical trials

GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

Phase N/A

Study of Palbociclib Alone and in Combination in Patients With Relapsed and Refractory (R/R) Leukemias

Study Arms: If you are found to be eligible to take part in this study, you will be assigned to a study Arm based on what the study doctor thinks is in your best interest. If you are in Arm A, you will receive palbociclib alone in Cycle 1. Beginning ...

Phase

Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised Targeted and Intensified Treatment

A phase IV study with the primary goal to optimize therapy of adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma (LBL) by dose and time intensive, pediatric based chemotherapy, risk adapted stem cell transplantation (SCT) and minimal residual disease (MRD) based individualised and intensified therapy. Study will further evaluate ...

Phase

Influences of High-fiber Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children

The gastrointestinal microbiome has been shown to be altered in critically-ill children such that there is a larger shift toward pathogenic bacteria. Previous studies have shown that probiotics, fecal transplants, antibiotic decontamination, and dietary interventions can shift the gastrointestinal microbiome toward a metabolically favorable microbiome profile and be associated with ...

Phase N/A

Blinatumomab and Ponatinib in Patients With Philadelphia Chromosome (Ph)-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Study Drug Administration: Each cycle is 6 weeks. The first cycle is called an Induction Cycle, in which the study drugs are designed to create a response from the disease. Cycles 2-5 are called Consolidation Cycles, in which the drugs are designed to keep that disease response going. Cycles 6 ...

Phase

Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

This is a Phase1/2 dose escalation study evaluating the safety and feasibility of BPX-501 infused after partially mismatched, related (haploidentical), T cell-depleted HSCT. The purpose of this clinical trial is to determine whether BPX-501 infusion can facilitate engraftment, enhance immune reconstitution and potentially improve the graft versus leukemia (GVL) effect, ...

Phase

Tac Mini-MTX MMF Versus Tac MTX for GVHD Prevention

Study Design This is a prospective randomized trial to determine the effectiveness of different doses of GVHD prophylaxis on mucositis, engraftment and aGVHD. Study consists of two study groups of 50 subjects each. Group A will receive Tac and MTX (15 mg/m2 day +1, 10 mg/m2 day +3, +6, +11). ...

Phase

De-escalated Treatment Approach for Adult Ph-negative Acute Lymphoblastic Leukemia (ALL)

7 days prednisolone prephase 8 weeks induction with de-escalation of induction chemotherapy: 3 instead of 4 dauno/vncr pulses, instead of 2 Cph injections during induction, instead of 4 ARA-C blocks, distribution of of L-asp injections through all phases After CR achievement T-cell ALL patients are being randomized to auto-HSCT vs ...

Phase N/A

Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS

Trial protocol intended the optimization of induction treatment with: Inclusion of PEG-ASP in induction and in the three blocks of consolidation. Reduction of the dose of daunorubicin, and recent studies have shown that the use of high doses of anthracyclines has not brought higher response rates or longer duration Replacing ...

Phase N/A

Double Cord Versus Haploidentical (BMT CTN 1101)

Reduced intensity conditioning (RIC) blood or marrow transplantation (BMT) has allowed older and less clinically fit patients to receive potentially curative treatment with allogeneic HCT for high risk or advanced hematological malignancies. Patients lacking an HLA-matched sibling may receive a graft from a suitably HLA-matched unrelated donor. However, up to ...

Phase