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Sarcoma (Pediatric) Clinical Trials

A listing of Sarcoma (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (19) clinical trials

Patients are needed to participate in a clinical research study evaluating Carboplatin, Vincristine, Bevacizumab, Irinotecan, Mebendazole, Temozolomide for the treatment of Diffuse Intrinsic Pontine Glioma, Pleomorphic Xanthoastrocytoma, Astrocytoma, Optic Nerve Glioma, gliosarcoma, Glioblastoma Multiforme, Brainstem Glioma, Low Grade Glioma, Pilomyxoid Astrocytoma, DIPG

This is a phase I/II study of mebendazole in combination with standard of care agents for pediatric patients with gliomas. Patients with low-grade gliomas will receive a regimen of mebendazole in combination with vincristine, carboplatin, and temozolomide. Patients with high-grade gliomas and diffuse intrinsic pontine gliomas will receive a regimen ...


Patients are needed to participate in a clinical research study for the treatment of childhood ALL, Lymphoma, leukemia

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

Phase N/A

A clinical research study of Vemurafenib

PRIMARY OBJECTIVES: I. To determine the objective response rate (ORR; complete response + partial response) in pediatric patients treated with vemurafenib with advanced solid tumors (including central nervous system [CNS] tumors), lymphomas or histiocytic disorders that harbor activating BRAF V600 mutations. SECONDARY OBJECTIVES: I. To estimate the progression free survival ...


Patients are needed to participate in a clinical research study evaluating Adavosertib

PRIMARY OBJECTIVES: I. To estimate the maximum tolerated dose (MTD) or recommended phase 2 dose and schedule of the WEE1 inhibitor AZD1775 (Wee1 inhibitor AZD1775 [MK-1775]) administered concurrently with radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). II. To define and describe the toxicities of WEE1 ...


Patients are needed to participate in a clinical research study of Central Nervous System Embryonal Tumors, Medulloblastoma to evaluate Tandem 3 Cycle Intensive Chemotherapy, Single Cycle Intensive Chemotherapy, Induction

Due to the inferior response and event-free survival data of Regimens D and D2 on "Head Start III" for all children with supratentorial embryonal tumors, in comparison with the published data from "Head Start II" with Regimen A2 for metastatic patients, all such patients will receive the "Head Start II" ...


A clinical trial to evaluate treatments using Toca FC, Temozolomide, Lomustine for patients with Glioblastoma Multiforme, Astrocytoma

This is a multicenter, randomized, open-label phase 2/3 study of Toca 511 and Toca FC versus standard of care that comprises Investigator's choice of single agent chemotherapy (lomustine or temozolomide) or bevacizumab administered to subjects undergoing resection for first or second recurrence (including this recurrence) of GBM or AA. Subjects ...


Patients are needed to participate in a clinical research study evaluating Gemcitabine, sonidegib, trametinib, ribociclib for the treatment of Refractory Brain Tumor, Medulloblastoma, PTCH1 Mutation, Meningioma, Ependymoma, Recurrent, Medulloblastoma, SHH-activated and TP53 Mutant, Pediatric Brain Tumor, Pleomorphic Xanthoastrocytoma, Anaplastic, Glioma, Recurrent Malignant, Malignant neoplasm of brain, Central Nervous System Neoplasms, Germ cell tumor, Embryonal Tumor of CNS, Medulloblastoma, Non-WNT/Non-SHH, CNS Embryonal Tumor With Rhabdoid Features, Medulloblastoma; Unspecified Site, Oligodendroglioma, Neuroectodermal Tumor, Anaplastic Ganglioglioma, Ependymoma, RELA Fusion Positive, Ganglioneuroblastoma of Central Nervous System, Atypical Teratoid Rhabdoid Tumor, Recurrent Medulloblastoma, Papillary Tumor of the Pineal Region (High-grade Only), Glioma, Recurrent High Grade, Gliomatosis cerebri, Embryonal Tumor With Multilayered Rosettes (ETMR), Pinealoma, Neuroblastoma. CNS, Glioblastoma, IDH-mutant, Medulloblastoma, Medulloblastoma, G3/G4, Glioblastoma Multiforme, Primitive neuroectodermal tumor, Ependymoma, NOS, WHO Grade III, Medulloblastoma, SHH-activated and TP53 Wildtype, Neuroepithelial Tumor, High Grade, Ependymoma, NOS, WHO Grade II, Glioma, Cancer, Astrocytoma, Medulloblastoma, Non-WNT Non-SHH, NOS, Choroid Plexus Carcinoma, Glioma, Diffuse Midline, H3K27M-mutant, Medulloblastoma, WNT-activated, Medulloblastoma, Group 3, Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only), Medulloblastoma, Group 4, Medulloblastoma, Chromosome 9q Loss, Glioma, High Grade, Glioblastoma, IDH-wildtype, Ependymoma

Patients will be stratified by the molecular and histologic characteristics of their tumor to one of three treatment strata. STRATUM A: Combination Treatment: ribociclib and gemcitabine. Patient Population: Participants with a diagnosis of refractory or recurrent medulloblastoma (Group 3/4) or refractory or recurrent ependymoma (including: ependymoma, not otherwise specified (NOS), ...


Targeted Marrow Irradiation Fludarabine Phosphate and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

PRIMARY OBJECTIVES: I. To determine the maximum tolerated dose of targeted marrow irradiation given in combination with fludarabine (fludarabine phosphate) and busulfan as conditioning regimen for allogeneic hematopoietic progenitor cell transplantation. SECONDARY OBJECTIVES: I. To describe the toxicity profile of the conditioning regimen of targeted marrow irradiation (TMI), fludarabine and ...


A Phase 3 clinical study for patients using Mycophenolate mofetil, methotrexate, Methotrexate (low dose), tacrolimus

Study Design This is a prospective randomized trial to determine the effectiveness of different doses of GVHD prophylaxis on mucositis, engraftment and aGVHD. Study consists of two study groups of 50 subjects each. Group A will receive Tac and MTX (15 mg/m2 day +1, 10 mg/m2 day +3, +6, +11). ...