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Congenital Heart Disease Clinical Trials

A listing of Congenital Heart Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (165) clinical trials

Physical Activity and Cognitive Development in Children

Mortality associated with congenital heart defects (CHD) has decreased significantly world-wide over the past decades. As more CHD patients are surviving beyond infancy and childhood, these patients are found to be at significant risk for developmental disabilities and developmental delay. In CHD patients, their neurodevelopmental impairments, as suggested by recent ...

Phase N/A

Preserved Umbilical Vein Use as Autologous Shunt Conduits in Neonatal Cardiac Surgery

This is a prospective, single center, safety and feasibility trial to evaluate the use of autologous umbilical vein as shunts or conduits in neonatal cardiac surgery. Subjects will be identified here at the Advanced Fetal Care Center (AFCC) following diagnosis of congenital heart disease (CHD) with single ventricle physiology of ...

Phase N/A

MitraClip and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect Closure

Transcatheter mitral valve repair with the MitraClip system is a therapeutic alternative to surgery in selected high-risk patients. Clip placement requires interatrial transseptal puncture and meticulous manipulation of the steerable sheath. There is evidence that the persistence of a relevant iASD after MitraClip is associated with worse clinical outcomes and ...

Phase N/A

The Effect of Dexmedetomidine on Kidney Perfusion in Paediatric Patients

I. Study design: open/ blinded randomized, controlled study. II. Study setting and location: The study will be conducted in Abul Reesh Paediatric Hospital Faculty of Medicine /Cairo University from 2016-2018. III. Study population: This controlled open/blinded labelled randomized study is designed to include 40 children of both sexes scheduled for ...


Study on the Relationship Between Maternal Exposure to Environmental Factors and Fetal Congenital Heart Disease

This is a community-based case-control study in SHANGHAI,a municipality in CHINA. Cases will be identified from maternity centers. Matched controls will be accrued from the same region as the case came from. Pregnant cases and their controls are women (18-45 years). Cases are gravidas with fetal congenital heart disease diagnosed ...

Phase N/A

Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Brain Training Program for Children With ASD

Visual puzzles have been used for centuries to facilitate early development in kids. Mental Imagery Therapy for Autism (MITA) is a unique, early-intervention application for children with Autism Spectrum Disorder (ASD). The app includes bright, interactive puzzles designed to help children learn how to mentally integrate multiple features of an ...

Phase N/A

The Effect on EPCs by Successful Cardiac Occlusion Device Implantation

The objective of this study is to assess the effect, if any, on EPC count and cardiac device implantation. All patients awaiting LAA or PFO/ASD occlusion will firstly be reviewed in a cardiology clinic and assessed. Suitable patients will then be placed on a waiting list for occlusion device implantation ...

Phase N/A

Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study

All participants will undergo a baseline liver magnetic resonance elastography. The patients with liver stiffness score >2.5 kiloPascal (KPa) [Normal: 2.5 KPa] will be enrolled in the study. In addition to a baseline liver MRE, all participants will undergo cardiac MRI, transthoracic echocardiogram (TTE), FibroSure (alpha-2 macroglobulin, haptoglobulin, gamma-glutamyltransferase, bilirubin, ...

Phase N/A

NOACs for Atrial Tachyarrhythmias in Congenital Heart Disease

Rationale: Adult patients with congenital heart disease (CHD) with atrial tachyarrhythmias need to be anticoagulated. It is not known whether non-vitamin K antagonist oral anticoagulants (NOAC) in this patient group are efficient and safe. Aim: The purpose of the NOTE registry is to evaluate the efficacy and safety of NOACs ...

Phase N/A

Observatory of Pulmonary Arterial Hypertension of Congenital Heart Disease

The complex congenital cardiac malformations are a significant number of different diseases, each having specific natural histories. The interface with pulmonary arterial hypertension (HTAP) is high since the physiology of many of these disorders comprises alterations in pulmonary vasculature. This observatory is a cohort of 400 patients enrolled in 3 ...

Phase N/A